ArticleNature communications2024
Mitoribosome structure with cofactors and modifications reveals mechanism of ligand binding and interactions with L1 stalk.
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31citing papers in PubMed
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Who cites it
31 citing papers in PubMed.
- Higher-order structural organization of mitochondrial metabolism.The Journal of biological chemistry · 2026Review
- RiboScreenBiomedicines · 2026Review
- Mechanisms and disease relevance of mitochondrial translation in humans.Nature reviews. Molecular cell biology · 2026Review
- Crosslinker nanocarrier-based intratumoral delivery for protein complex mapping in mitochondria of live tumor-bearing mice.Chemical science · 2026Article
- Architectural principles of the ribosomal large subunit revealed by A-helix spatial organization.Scientific reports · 2026Article
- Membrane insertion of mitochondrial-encoded proteins regulates ribosome decoding speed.Nature structural & molecular biology · 2026Article
- Structural basis of TACO1-mediated efficient mitochondrial translation.Nature communications · 2026Article
- CryoAtom improves model building for cryo-EM.Nature structural & molecular biology · 2026Article
- Fungi between threat and promise: global perspectives on health and innovation.Frontiers in microbiology · 2026Review
- Structural Basis of TACO1-Mediated Efficient Mitochondrial Translation.bioRxiv : the preprint server for biology · 2025Article
- Structural insights into cauliflower mitoribosome in translation state and in association with a late assembly factor.Nature communications · 2025Article
- The late stages of yeast mitoribosome large subunit biogenesis.Biochimica et biophysica acta. Molecular cell research · 2025Article
- The function of Mak16 in ribosome biogenesis depends on its [4Fe-4S] cluster.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mettl15-Mettl17 modulates the transition from early to late pre-mitoribosome.Structure (London, England : 1993) · 2025Article
- Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer.Nature genetics · 2025Article
- Structure of an archaeal ribosome reveals a divergent active site and hibernation factor.Nature microbiology · 2025Article
- Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss.FEBS open bio · 2025Article
- Emerging mechanisms of human mitochondrial translation regulation.Trends in biochemical sciences · 2025Review
- The mitochondrial methylation potential gates mitoribosome assembly.Nature communications · 2025Article
- Simulating biomolecules for physiological timescales.Current opinion in structural biology · 2025Review
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Authors and funding
14 authors.
Vivek Singh *Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 17165, Solna, Sweden.ORCID http://orcid.org/0000-0003-4656-3362
Yuzuru Itoh *Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 17165, Solna, Sweden.ORCID http://orcid.org/0000-0001-7802-5572
Samuel Del'Olio *Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
Asem Hassan *Department of Physics, Northeastern University, Boston, MA, 02115, USA.ORCID http://orcid.org/0000-0003-0220-195X
Andreas NaschbergerScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 17165, Solna, Sweden.
Rasmus Kock FlygaardDepartment of Molecular Biology and Genetics, Danish Research Institute of Translational Neuroscience - DANDRITE, Nordic EMBL Partnership for Molecular Medicine, Aarhus University, 8000, Aarhus C, Denmark.
Yuko NobeDepartment of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Minami-osawa 1-1, Hachioji-shi, Tokyo, 192-0397, Japan.ORCID http://orcid.org/0000-0001-6375-983X
Keiichi IzumikawaDepartment of Molecular and Cellular Biochemistry, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose-shi, Tokyo, 204-8588, Japan.
Shintaro AibaraScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 17165, Solna, Sweden.ORCID http://orcid.org/0000-0003-2221-482X
Juni AndréllDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-2313-9155
Paul C WhitfordDepartment of Physics, Northeastern University, Boston, MA, 02115, USA.ORCID http://orcid.org/0000-0001-7104-2265
Antoni BarrientosDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.ORCID http://orcid.org/0000-0001-9018-3231
Masato TaokaDepartment of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Minami-osawa 1-1, Hachioji-shi, Tokyo, 192-0397, Japan.ORCID http://orcid.org/0000-0001-5554-4951
Alexey AmuntsScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 17165, Solna, Sweden. alexey.amunts@gmail.com.ORCID http://orcid.org/0000-0002-5302-1740
Funding
Mitochondrial Biogenesis in Health and DiseaseR35GM118141 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BARRIENTOS, ANTONI · 2016 to 2025
$8.9MDH | NIHR | Health Services Research Programme (NIHR Health Services Research Programme) GM118141EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) ERC-2018-StG-805230Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation) 2018.0080MEXT | Japan Science and Technology Agency (JST) 19198049NIGMS NIH HHS R35 GM118141Ragnar Söderbergs stiftelse (Ragnar Söderberg Foundation) M44/16Stiftelsen för Strategisk Forskning (Swedish Foundation for Strategic Research) FFL15:0325United States Department of Defense | Missile Defense Agency (MDA) MDA-381828
Abstract
The mitoribosome translates mitochondrial mRNAs and regulates energy conversion that is a signature of aerobic life forms. We present a 2.2 Å resolution structure of human mitoribosome together with validated mitoribosomal RNA (rRNA) modifications, including aminoacylated CP-tRNA
Indexed as
Mitochondrial RibosomesRNA, TransferGuanosine DiphosphateHumansLigandsMitochondriaMolecular Dynamics SimulationPolyaminesProtein BindingRibosomal ProteinsRNA, MessengerRNA, RibosomalGuanosine DiphosphateLigandsPolyaminesRibosomal ProteinsRNA, MessengerRNA, RibosomalRNA, Transfer
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.