Evidence map›Paper›PMID 38771147›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2024

Role of STIM1 in stretch-induced signaling in human airway smooth muscle.

Yang Yao, Mengning Zheng, Niyati A Borkar, Michael A Thompson, Emily Y Zhang, Maunick Lefin Koloko Ngassie, Shengyu Wang, Christina M Pabelick, Elizabeth R Vogel, Y S Prakash

Abstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Asthma endotypes and theratypes.Chinese medical journal pulmonary and critical care medicine · 2026
    Review
  4. Review
  5. Article
  6. The importance of mechanical forces in chronic respiratory diseases.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  7. Review
  8. Mechanical stretch promotes sustained proliferation and inflammation in developing human airway smooth muscle.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yang YaoDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Medical University, Xi'an, People's Republic of China.
Mengning ZhengDepartment of Respiratory and Critical Care Medicine, Guizhou Province People's Hospital, Guiyang, People's Republic of China.
Niyati A BorkarDepartment of Anesthesiology, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-7919-8798
Michael A ThompsonDepartment of Anesthesiology, Mayo Clinic, Rochester, Minnesota, United States.
Emily Y ZhangDepartment of Anesthesiology, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0001-8156-5369
Maunick Lefin Koloko NgassieDepartment of Anesthesiology, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0003-2899-3983
Shengyu WangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Medical University, Xi'an, People's Republic of China.
Christina M PabelickDepartment of Anesthesiology, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-4632-2174
Elizabeth R VogelDepartment of Anesthesiology, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0001-6537-5098
Y S PrakashDepartment of Anesthesiology, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-2968-224X

Funding

NEURAL REGULATION OF AIRWAYS DURING POSTNATAL MATURATIONR01HL056470 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S. · 1996 to 2025
$10.5M
Nicotine, Airway Smooth Muscle and AsthmaR01HL142061 · NHLBI · MAYO CLINIC ROCHESTER · PI PABELICK, CHRISTINA MARIA, PRAKASH, Y. S. · 2019 to 2022
$2.0M
SURFACTANT DEFICIENCY AND AIR POLLUTION SUSCEPTIBILITYR01HL058275 · NHLBI · UNIVERSITY OF CINCINNATI · PI LEIKAUF, GEORGE DOUGLAS · 1996 to 1998
–
2023 Shaanxi University Youth Innovation Team 79American Heart Association (AHA) https://doi.org/10.58275/AHA.24POST1241979.pc.gr.190840Foundation of Anesthesia Education and Research Mentored Research Training Grant FAER MRTGHHS | National Institutes of Health (NIH) R01-HL056470HHS | National Institutes of Health (NIH) R01-HL142061| Key Science and Technology Program of Shaanxi Province () 2020SF-062NHLBI NIH HHS R01 HL056470NHLBI NIH HHS R01 HL142061Science and Technology Department of Guizhou Province ZK[2021]351
6 · The paper itself

Abstract

Alteration in the normal mechanical forces of breathing can contribute to changes in contractility and remodeling characteristic of airway diseases, but the mechanisms that mediate these effects in airway cells are still under investigation. Airway smooth muscle (ASM) cells contribute to both contractility and extracellular matrix (ECM) remodeling. In this study, we explored ASM mechanisms activated by mechanical stretch, focusing on mechanosensitive piezo channels and the key Ca

Indexed as

Myocytes, Smooth MuscleStromal Interaction Molecule 1Airway RemodelingCalciumCaveolin 1Cells, CulturedHumansInflammasomesIon ChannelsMechanotransduction, CellularMuscle ContractionMuscle, SmoothNeoplasm ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinORAI1 ProteinSignal TransductionCalciumCaveolin 1InflammasomesIon ChannelsNeoplasm ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinORAI1 ProteinPIEZO1 protein, humanSTIM1 protein, humanStromal Interaction Molecule 1asthmainflammasomemechanobiologymechanosensitivitystore-operated calcium entry

Identifiers

PMID38771147
PMCPMC11687955

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.