ReviewIntensive care medicine2024
Nutrition in the intensive care unit: from the acute phase to beyond.
Review in Intensive care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- High-protein supplementation in critically ill patients: a systematic review, meta-analysis and umbrella review of existing evidence.Frontiers in nutrition · 2026Pooled it
- The urea-to-creatinine ratio as an emerging biomarker in critical care: a scoping review and meta-analysis.Critical care (London, England) · 2025Pooled it
- Impact of nutritional support on mortality among critically ill patients with different nutritional risks: a systematic review with meta-analysis.Frontiers in nutrition · 2025Pooled it
- Combined intravenous bolus amino acid supplementation and mobilization on early muscle loss in critically ill adults: A randomized controlled trial.JPEN. Journal of parenteral and enteral nutrition · 2026Trial
- Changes in Muscle Mass and Quality Mediate the Effect of High-Calorie Intake on Clinical Outcomes.Journal of cachexia, sarcopenia and muscle · 2026Article
- Feeding or Failing? Rethinking Nutrition Therapy in Pediatric Critical Care.Current nutrition reports · 2026Review
- Timing-specific neutrality in a rigorous ICU anabolic trial.JPEN. Journal of parenteral and enteral nutrition · 2026Article
- Reply to "Mechanical tension and autophagy suppression: Unmasking the confounders in ICU muscle preservation strategies".JPEN. Journal of parenteral and enteral nutrition · 2026Article
- Reply to: Timing-specific neutrality in a Rigorous ICU anabolic trial.JPEN. Journal of parenteral and enteral nutrition · 2026Article
- Time course of energy expenditure in persistent critical illness: a prospective multicentre study.Critical care (London, England) · 2026Observational
- Article
- Diabetes Management Strategies in Intensive Care Settings.The Medical clinics of North America · 2026Review
- Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials.Experimental physiology · 2026Review
- β-Nicotinamide mononucleotide preserves muscle strength in septic male mice.Scientific reports · 2026Article
- Cost Analysis of Individualized Parenteral Nutrition Bags in a Saudi Tertiary-Care Hospital: A Retrospective Cohort Study and Implications for Cost-Effective Clinical Practice.Healthcare (Basel, Switzerland) · 2026Article
- Intensive Care Unit Acquired Weakness as a Modifiable Organ Dysfunction? A Narrative Review of Evolving Diagnostic and Therapeutic Concepts.Nutrients · 2026Review
- Core outcome sets and trials of nutrition and metabolism interventions.Current opinion in clinical nutrition and metabolic care · 2026Review
- Detecting the metabolic transition to personalize nutritional timing: model development and preliminary validation in a large ICU cohort.Critical care (London, England) · 2026Article
- Advances and Challenges in Obstetric Intensive Care Medicine.Journal of clinical medicine · 2026Review
- Self-efficacy in nutritional care for older adults among hospital-based nurses: a latent profile and network simulation analysis.BMC nursing · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent randomized controlled trials (RCTs) have shown no benefit but dose-dependent harm by early full nutritional support in critically ill patients. Lack of benefit may be explained by anabolic resistance, suppression of cellular repair processes, and aggravation of hyperglycemia and insulin needs. Also early high amino acid doses did not provide benefit, but instead associated with harm in patients with organ dysfunctions. However, most studies focused on nutritional interventions initiated during the first days after intensive care unit admission. Although the intervention window of some RCTs extended into the post-acute phase of critical illness, no large RCTs studied nutritional interventions initiated beyond the first week. Hence, clear evidence-based guidance on when and how to initiate and advance nutrition is lacking. Prolonged underfeeding will come at a price as there is no validated metabolic monitor that indicates readiness for medical nutrition therapy, and an adequate response to nutrition, which likely varies between patients. Also micronutrient status cannot be assessed reliably, as inflammation can cause redistribution, so that plasma micronutrient concentrations are not necessarily reflective of total body stores. Moreover, high doses of individual micronutrients have not proven beneficial. Accordingly, current evidence provides clear guidance on which nutritional strategies to avoid, but the ideal nutritional regimen for individual patients remains unclear. In this narrative review, we summarize the findings of recent studies, discuss possible mechanisms explaining the results, point out pitfalls in interpretation of RCTs and their effect on clinical practice, and formulate suggestions for future research.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.