Evidence map›Paper›PMID 38772361›Full record

ArticleCurrent biology : CB2024

Elevated sleep quota in a stress-resilient Drosophila species.

Jessica Yano, Ceazar Nave, Katherine Larratt, Phia Honey, Makayla Roberts, Cassandra Jingco, Melanie L Fung, Damion Trotter, Xin He, Gazmend Elezi and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Jessica YanoDepartment of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Molecular, Cellular & Integrative Physiology Interdepartmental PhD Program, UCLA, Los Angeles, CA 90095, USA.
Ceazar NaveDepartment of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Katherine LarrattDepartment of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Phia HoneyDepartment of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Department of Neuroscience, Wellesley College, Wellesley, MA 02481, USA.
Makayla RobertsDepartment of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Cassandra JingcoDepartment of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Melanie L FungDepartment of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Damion TrotterDepartment of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Molecular, Cellular & Integrative Physiology Interdepartmental PhD Program, UCLA, Los Angeles, CA 90095, USA.
Xin HeDepartment of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Gazmend EleziPasarow Mass Spectrometry Laboratory, Jane & Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Cotsen Institute of Archaeology, UCLA, Los Angeles, CA 90095, USA.
Julian P WhiteleggePasarow Mass Spectrometry Laboratory, Jane & Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Sara WassermanDepartment of Neuroscience, Wellesley College, Wellesley, MA 02481, USA.
Jeffrey M DonleaDepartment of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address: jdonlea@ucla.edu.

Funding

UPLIFT: UCLA Postdocs' Longitudinal Investment in Faculty TrainingK12GM106996 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAREY, MICHAEL F, VILLANUEVA, CLAUDIO J · 2016 to 2025
$7.1M
Investigating the role of sleep in synaptic reorganization after neural injuryR01NS119905 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jeffrey Michael Donlea · 2022 to 2026
$1.9M
Investigating the logic of homeostatic sleep control circuitry in DrosophilaR01NS105967 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DONLEA, JEFFREY MICHAEL · 2018 to 2022
$1.7M
NIGMS NIH HHS K12 GM106996NINDS NIH HHS R01 NS105967NINDS NIH HHS R01 NS119905
6 · The paper itself

Abstract

Sleep is broadly conserved across the animal kingdom but can vary widely between species. It is currently unclear which selective pressures and regulatory mechanisms influence differences in sleep between species. The fruit fly Drosophila melanogaster has become a successful model system for examining sleep regulation and function, but little is known about the sleep patterns in many related fly species. Here, we find that fly species with adaptations to extreme desert environments, including D. mojavensis, exhibit strong increases in baseline sleep compared with D. melanogaster. Long-sleeping D. mojavensis show intact homeostasis, indicating that desert flies carry an elevated drive for sleep. In addition, D. mojavensis exhibit altered abundance or distribution of several sleep/wake-related neuromodulators and neuropeptides that are consistent with their reduced locomotor activity and increased sleep. Finally, we find that in a nutrient-deprived environment, the sleep patterns of individual D. mojavensis are strongly correlated with their survival time and that disrupting sleep via constant light stimulation renders D. mojavensis more sensitive to starvation. Our results demonstrate that D. mojavensis is a novel model for studying organisms with high sleep drive and for exploring sleep strategies that provide resilience in extreme environments.

Indexed as

DrosophilaSleepAnimalsDesert ClimateDrosophila melanogasterFemaleMaleSpecies SpecificityStress, PhysiologicalDrosophilaflyfood deprivationmojavensisoctopamineserotoninsleep

Identifiers

PMID38772361
PMCPMC11163955

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.