Evidence map›Paper›PMID 38772880›Full record

ArticleBMJ open diabetes research & care2024

Prospective associations between breast feeding, metabolic health, inflammation and bone density in women with prior gestational diabetes mellitus.

Ines Hebeisen, Elena Gonzalez Rodriguez, Amar Arhab, Justine Gross, Sybille Schenk, Leah Gilbert, Katrien Benhalima, Antje Horsch, Dan Yedu Quansah, Jardena J Puder

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In one paragraph

Article in BMJ open diabetes research & care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Sustained Reduction of Subclinical Inflammation in the Years After Breastfeeding.The Journal of clinical endocrinology and metabolism · 2025
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ines HebeisenObstetric Service, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland.ORCID 0009-0006-9213-3135
Elena Gonzalez RodriguezInterdisciplinary Center of Bone Diseases, Bone and Joint Department, Lausanne University Hospital, Lausanne, Switzerland.
Amar ArhabObstetric Service, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland.ORCID 0000-0002-8938-5095
Justine GrossService of Endocrinology, Diabetes and Metabolism, Department of Medicine, CHUV, Lausanne, Switzerland.
Sybille SchenkService of Obsterics, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland.
Leah GilbertObstetric Service, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland.
Katrien BenhalimaDepartment of Endocrinology, KUL UZ Gasthuisberg, Leuven, Belgium.
Antje HorschNeonatology service, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland.
Dan Yedu QuansahObstetric Service, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland.ORCID 0000-0002-3091-9400
Jardena J PuderObstetric Service, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland Jardena.puder@chuv.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of the study is to investigate prospective associations between breastfeeding and metabolic outcomes, inflammation, and bone density in women with prior gestational diabetes mellitus (GDM). RESEARCH DESIGN AND

methodsWe prospectively included 171 women with GDM from the MySweetheart trial. Women were followed during pregnancy (from 24 up to 32 weeks' gestational age) up to 1 year postpartum. Outcomes included weight, weight retention, body composition, insulin resistance and secretion indices, C reactive protein (CRP), and bone density. We compared differences in the associations between breastfeeding and health outcomes between women who breast fed <6 months vs ≥6 months. Analyses were adjusted for potential medical and sociodemographic confounders.

resultsBreastfeeding initiation was 94.2% (n=161) and mean breastfeeding duration was 6.6 months. Breastfeeding duration was independently associated with lower weight, weight retention, body fat, visceral adipose tissue, lean mass, CRP, insulin resistance (Homeostatic Model Assessment for Insulin Resistance), and insulin secretion (Homeostatic Model Assessment of β-cell index) at 1 year postpartum (all p≤0.04) after adjusting for confounders. Breastfeeding was associated with higher insulin resistance-adjusted insulin secretion (Insulin Secretion-Sensitivity Index-2) in the unadjusted analyses only. There was no association between breastfeeding duration and bone density. Compared with <6 months, breastfeeding duration ≥6 months was associated with lower weight, weight retention, body fat, fat-free mass as well as lower CRP at 1 year postpartum (all p<0.05) after adjusting for confounders.

conclusionsLonger breastfeeding duration among women with prior GDM was associated with lower insulin resistance, weight, weight retention, body fat and inflammation, but not lower bone density at 1 year postpartum. Breastfeeding for ≥6 months after GDM can help to improve cardiometabolic health outcomes 1 year after delivery.

Indexed as

Bone DensityBreast FeedingDiabetes, GestationalInflammationInsulin ResistanceAdultBiomarkersBody CompositionFemaleFollow-Up StudiesHumansPostpartum PeriodPregnancyProspective StudiesBiomarkersBody FatBody WeightBone DensityGDM

Identifiers

PMID38772880
PMCPMC11110608

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.