Evidence map›Paper›PMID 38772978›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2024

Hypertension control after intracerebral hemorrhage among varying small vessel disease etiologies.

Alvin S Das, Akashleena Mallick, Samantha A Mora, Sophia Keins, Jessica R Abramson, Juan Pablo Castello, Marco Pasi, Christina E Kourkoulis, Axana Rodriguez-Torres, Andrew D Warren and 7 more

Abstract read
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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Alvin S Das *Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. adas4@bidmc.harvard.edu.ORCID http://orcid.org/0000-0003-2313-977X
Akashleena Mallick *Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Samantha A MoraDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Sophia KeinsDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Jessica R AbramsonDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Juan Pablo CastelloDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Marco PasiUniversité de Tours, CHU Tours, Tours, France.
Christina E KourkoulisDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Axana Rodriguez-TorresDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Andrew D WarrenDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Elif GökçalDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Anand ViswanathanDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Steven M GreenbergDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Christopher D AndersonDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Jonathan RosandDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Alessandro Biffi *Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
M Edip Gurol *Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. megurol@mgh.harvard.edu.

Funding

CEREBRAL AMYLOID ANGIOPATHY AND MECHANISMS OF BRAIN AMYLOID ACCUMULATIONR01NS096730 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BACSKAI, BRIAN J, GREENBERG, STEVEN M · 2016 to 2020
$5.7M
Molecular and Physiological Mechanisms of Hypertensive Cerebral MicroangiopathyR01NS114526 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI GUROL, MAHMUT EDIP · 2020 to 2024
$4.4M
Sequencing Annotation and Functional Analysis in Risk of Intracerebral HemorrhageR01NS103924 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ANDERSON, CHRISTOPHER DAVID · 2018 to 2022
$3.4M
Molecular Neuroimaging of Disease Mechanisms in Cerebral Amyloid AngiopathyK23NS083711 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI GUROL, MAHMUT EDIP · 2014 to 2018
$988k
American Heart Association 21SFRN812095Andrew David Heitman Foundation 1200-236980NINDS NIH HHS 5R01AG026484NINDS NIH HHS 5R01NS096730-04NINDS NIH HHS NS083711NINDS NIH HHS R01NS103924NINDS NIH HHS R01NS114526NINDS NIH HHS U01NS069673
6 · The paper itself

Abstract

introductionIntracerebral hemorrhage (ICH) is attributable to cerebral small vessel disease (cSVD), which includes cerebral amyloid angiopathy (CAA) and hypertensive-cSVD (HTN-cSVD). HTN-cSVD includes patients with strictly deep ICH/microbleeds and mixed location ICH/microbleeds, the latter representing a more severe form of HTN-cSVD. We test the hypothesis that more severe forms of HTN-cSVD are related to worse hypertension control in long-term follow-up after ICH.

methodsFrom consecutive non-traumatic ICH patients admitted to a tertiary care center, we classified the ICH as CAA, strictly deep ICH/microbleeds, and mixed-location ICH/microbleeds. CSVD burden was quantified using a validated MRI-based score (range: 0-6 points). We created a multivariable (linear mixed effects) model adjusting for age, sex, race, year of inclusion, hypertension, and antihypertensive medication usage to investigate the association of average systolic blood pressure (SBP) during follow-up with cSVD etiology/severity.

results796 ICH survivors were followed for a median of 48.8 months (IQR 41.5-60.4). CAA-related ICH survivors (n = 373) displayed a lower median SBP (138 mmHg, IQR 133-142 mmHg) compared to those of strictly deep ICH (n = 222, 141 mmHg, IQR 136-143 mmHg, p = 0.04), and mixed location ICH/microbleeds (n = 201, 142 mmHg, IQR 135-144 mmHg, p = 0.02). In the multivariable analysis, mixed location ICH/microbleeds (effect: + 3.8 mmHg, SE: 1.3 mmHg, p = 0.01) and increasing cSVD severity (+ 1.8 mmHg per score point, SE: 0.8 mmHg, p = 0.03) were associated with higher SBP in follow-up.

conclusionCSVD severity and subtype predicts long-term hypertension control in ICH patients.

Indexed as

Cerebral HemorrhageCerebral Small Vessel DiseasesHypertensionAgedAged, 80 and overAntihypertensive AgentsBlood PressureCerebral Amyloid AngiopathyFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesSeverity of Illness IndexAntihypertensive AgentsCerebral small vessel diseasesHypertensionIntracerebral hemorrhageNeuroimaging

Identifiers

PMID38772978

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.