Evidence map›Paper›PMID 38773493›Full record

ArticleBMC infectious diseases2024

Seroprevalence and placental transfer of SARS-CoV-2 antibodies in unvaccinated pregnant women.

An Vercoutere, Mbiton Joel Zina, Meltem Telis, Jean-Christophe Goffard, Michel Boulvain, Loïc de Doncker, Sara Derisbourg, Sylvie Houben, Marie-Luce Delforge, Caroline Daelemans and 1 more

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Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

An VercoutereDepartment of Obstetrics and Gynaecology, Hôpital Erasme, Hôpital Universitaire de Bruxelles (H.U.B.), Route de Lennik 808, 1070, Brussels, Belgium. an.vercoutere@hubruxelles.be.
Mbiton Joel ZinaOutbreak Support Team Carolo, Charleroi Hainaut, Belgium.
Meltem TelisDepartment of Neonatology, Hôpital Erasme, Hôpital Universitaire de Bruxelles (H.U.B.), Brussels, Belgium.
Jean-Christophe GoffardDepartment of Internal Medicine, Hôpital Erasme, Hôpital Universitaire de Bruxelles (H.U.B.), Brussels, Belgium.
Michel BoulvainDepartment of Obstetrics and Gynaecology, Hôpital Erasme, Hôpital Universitaire de Bruxelles (H.U.B.), Route de Lennik 808, 1070, Brussels, Belgium.
Loïc de DonckerInstitute for Medical Immunology, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Sara DerisbourgDepartment of Obstetrics and Gynaecology, Hôpital Erasme, Hôpital Universitaire de Bruxelles (H.U.B.), Route de Lennik 808, 1070, Brussels, Belgium.
Sylvie HoubenDepartment of Obstetrics and Gynaecology, Hôpital Delta, Chirec Hospitals, Brussels, Belgium.
Marie-Luce DelforgeNational Reference Center for Congenital Infections, Hôpital Erasme, Hôpital Universitaire de Bruxelles (H.U.B.), Brussels, Belgium.
Caroline Daelemans *Department of Woman, Child and Adolescent Medicine, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Dorottya Kelen *Department of Neonatology, Hôpital Erasme, Hôpital Universitaire de Bruxelles (H.U.B.), Brussels, Belgium.

Funding

Fonds De La Recherche Scientifique - FNRS CUR - 40002813, 2020
6 · The paper itself

Abstract

purposePregnant women are at risk of severe SARS-CoV-2 infection, potentially leading to obstetric and neonatal complications. Placental transfer of antibodies directed to SARS-CoV-2 may be protective against neonatal COVID-19, but this remains to be studied. We aimed to determine the seroprevalence of SARS-CoV-2 antibodies in a population of unvaccinated pregnant women and to determine the placental transfer of these antibodies. METHODOLOGY: A total of 1197 unvaccinated women with mostly unknown pre-study SARS-CoV-2 infection status, were tested at delivery for SARS-CoV-2 spike protein IgG antibodies during the first year of the pandemic. Umbilical cord samples were collected and assessed for seropositivity if the mother was seropositive. Maternal characteristics, pregnancy and neonatal outcomes and data on SARS-CoV-2 infection were extracted from medical records.

resultsSpecific IgG were detected in 258 women (21.6%). A significant placental transfer to the newborn was observed in 81.3% of cases. The earlier in the 2nd and 3rd trimesters that the mother had contracted the disease and the more symptomatic she was, the greater the likelihood of transplacental transfer of IgG to her newborn.

conclusionApproximately one in five women had detectable anti-SARS-CoV-2 spike protein IgG antibodies at delivery during the first year of the pandemic, and these antibodies were significantly transferred to their fetuses. This research provides further evidence to better understand the dynamics of the placental transfer of SARS-CoV-2 IgG antibodies from mothers to their newborns, which is necessary to improve vaccination strategies.

Indexed as

Antibodies, ViralCOVID-19Immunoglobulin GPregnancy Complications, InfectiousSARS-CoV-2AdultFemaleHumansInfant, NewbornInfectious Disease Transmission, VerticalMaternal-Fetal ExchangePlacentaPregnancySeroepidemiologic StudiesSpike Glycoprotein, CoronavirusUnvaccinated PersonsAntibodies, ViralImmunoglobulin GSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2AntibodyCOVID-19Placental transferPregnancySARS-COV-2 antibodiesSeroprevalence

Identifiers

PMID38773493
PMCPMC11110414

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.