ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Association of LIfestyle for BRAin health risk score (LIBRA) and genetic susceptibility with incident dementia and cognitive decline.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of brain health in adults with chronic pain.Anaesthesia · 2026Pooled it
- Lifestyle for Brain health (LIBRA) score, cognition, brain volume, and dementia risk in the UK Biobank.GeroScience · 2026Article
- Oral anticoagulant use and incident dementia in atrial fibrillation by baseline LIBRA score: a population-based cohort study using the 45 and up study.GeroScience · 2026Article
- Brain Health and Traumatic Brain Injury (TBI): Relationship Between Brain Care Score and Disability in Subacute-Long Term TBI.American journal of lifestyle medicine · 2026Article
- Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology.Nature communications · 2026Article
- APOE genotype, cardiovascular risk, and incident dementia in the Norwegian HUNT study.European journal of epidemiology · 2026Article
- Co-Designing a Digital Brain Health Intervention for Chinese Older Adults: A User-Centred Approach.Australasian journal on ageing · 2026Article
- Article
- Higher plasma omega-6 fatty acids are associated with lower dementia risk: evidence from NMR metabolomics and Alzheimer's disease polygenic risk in the UK Biobank.Frontiers in public health · 2026Article
- Measures of retinal health successfully capture risk for Alzheimer's disease and related dementias at midlife.Journal of Alzheimer's disease : JAD · 2025Article
- The LIBRA index of modifiable risk factors for mild cognitive impairment and dementia in a late-life population-based cohort study.AJE advances : research in epidemiology · 2025Article
- Lifestyle, genetic risk, plasma pTau217, and incident cognitive impairment in WRAP.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Lifestyle and cognition: Separating the effects of average lifestyle and lifestyle changes based on the LIBRA score.The journal of prevention of Alzheimer's disease · 2025Article
- Association of LIfestyle for BRAin health risk score (LIBRA) and genetic susceptibility with incident dementia and cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Applications and implicit assumptions in dementia risk scores: A scoping review of the LIBRA score.Journal of Alzheimer's disease reportsReview
- Heterogeneous trajectories of executive function in clinical Alzheimer's disease: Results from the 3C study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
14 authors.
Funding
Abstract
introductionEvaluating whether genetic susceptibility modifies the impact of lifestyle-related factors on dementia is critical for prevention.
methodsWe studied 5170 participants from a French cohort of older persons free of dementia at baseline and followed for up to 17 years. The LIfestyle for BRAin health risk score (LIBRA) including 12 modifiable factors was constructed at baseline (higher score indicating greater risk) and was related to both subsequent cognitive decline and dementia incidence, according to genetic susceptibility to dementia (reflected by the apolipoprotein E [APOE] ε4 allele and a genetic risk score [GRS]).
resultsThe LIBRA was associated with higher dementia incidence, with no significant effect modification by genetics (hazard ratio for one point score = 1.09 [95% confidence interval, 1.05; 1.13]) in APOE ε4 non-carriers and = 1.15 [1.08; 1.22] in carriers; P = 0.15 for interaction). Similar findings were obtained with the GRS and with cognitive decline. DISCUSSION: Lifestyle-based prevention may be effective whatever the genetic susceptibility to dementia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.