Evidence map›Paper›PMID 38775856›Full record

ArticleAIDS and behavior2024

Associations Between Alcohol Use, Antiretroviral Therapy Use, and Viral Load Suppression Among People Living with HIV in Rural Central Uganda.

Adriane Wynn, Katelyn M Sileo, Katherine Schmarje Crockett, Rose Naigino, Michael Ediau, Nicolas A Menzies, Seth C Kalichman, Rhoda K Wanyenze, Natasha K Martin, Susan M Kiene

Abstract read
In one paragraph

Article in AIDS and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Adriane WynnDivision of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-8067-3616
Katelyn M SileoDepartment of Public Health, The University of Texas at San Antonio, San Antonio, TX, USA.
Katherine Schmarje CrockettDivision of Epidemiology and Biostatistics, School of Public Health, San Diego State University, 5500 Campanile Drive (MC-4162), San Diego, CA, 92182, USA.
Rose NaiginoDivision of Epidemiology and Biostatistics, School of Public Health, San Diego State University, 5500 Campanile Drive (MC-4162), San Diego, CA, 92182, USA.
Michael EdiauDivision of Epidemiology and Biostatistics, School of Public Health, San Diego State University, 5500 Campanile Drive (MC-4162), San Diego, CA, 92182, USA.
Nicolas A MenziesHarvard T.H Chan School of Public Health, Boston, MA, USA.
Seth C KalichmanDepartment of Psychological Sciences, University of Connecticut, Storrs, CT, USA.
Rhoda K WanyenzeDepartment of Disease Control and Environmental Health, Makerere University School of Public Health, Kampala, Uganda.
Natasha K MartinDivision of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA, USA.
Susan M KieneDivision of Epidemiology and Biostatistics, School of Public Health, San Diego State University, 5500 Campanile Drive (MC-4162), San Diego, CA, 92182, USA. skiene@sdsu.edu.ORCID http://orcid.org/0000-0001-8922-5289

Funding

Enhanced Linkage to HIV Care Following Home-Based HIV Testing in Rural UgandaR01MH106391 · NIMH · SAN DIEGO STATE UNIVERSITY · PI KIENE, SUSAN MARIA, WANYENZE, RHODA KITTI · 2015 to 2019
$3.4M
Modeling reductions in harmful alcohol use on HIV transmission and mortality in the era of universal test and treat in UgandaK01AA027733 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WYNN, ADRIANE MICHELLE · 2020 to 2024
$888k
National Institute for Academic Anaesthesia K01AA027733NIAAA NIH HHS K01 AA027733NIMH NIH HHS R01 MH106391NIMH NIH HHS R01MH106391
6 · The paper itself

Abstract

Alcohol use among people living with HIV (PWH) is common and may negatively affect engagement in HIV care. We evaluated the relationships between alcohol use, ART use, and viral suppression among PWH in Uganda. PATH/Ekkubo was a trial evaluating a linkage to HIV care intervention in four Ugandan districts, Nov 2015-Sept 2021. Our analytical sample included: (1) baseline data from individuals not enrolled in the intervention trial (previously diagnosed HIV+); and 12-month follow-up data from the control group (newly diagnosed or previously diagnosed, but not in care). Level of alcohol use was categorized using the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C): none (AUDIT-C = 0), low (women = 1-2, men = 1-3), medium (women = 3-5, men = 4-5), high/very high (6-12). Multivariable logistic regression models evaluated associations between alcohol use, ART use and viral suppression (a viral load of < 20); we also stratified by gender. Among 931 PWH, medium (OR: 0.43 [95% CI 0.25-0.72]) and high/very high (OR: 0.22 [95% CI 0.11-0.42]) levels of alcohol use were associated with lower odds of being on ART. In a sub-sample of 664, medium use (OR: 0.63 [95% CI 0.41-0.97]) was associated with lower odds of viral suppression. However, this association was not statistically significant when restricting to those on ART, suggesting the relationship between alcohol use and viral suppression is explained by ART use. Among men, high/very high, and among women, medium alcohol use levels were associated with lower odds of being on ART and being virally suppressed. Interventions for PWH who use higher levels of alcohol may be needed to optimize the benefits of Uganda's Universal Test and Treat strategy.

Indexed as

Alcohol DrinkingHIV InfectionsRural PopulationViral LoadAdultAnti-HIV AgentsAnti-Retroviral AgentsFemaleHumansMaleMiddle AgedUgandaYoung AdultAnti-HIV AgentsAnti-Retroviral AgentsAlcohol useARTCross-sectional studyHIVUgandaViral suppression

Identifiers

PMID38775856
PMCPMC11199259

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.