ArticleAging clinical and experimental research2024
Stroke and frailty index: a two-sample Mendelian randomisation study.
Article in Aging clinical and experimental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Prediction model for frailty risk in ischemic stroke patients: Application and validation of support vector machines and nomograms.Medicine · 2026Article
- Dynamic frailty and depressive symptoms in relation to incident stroke: findings from five harmonized longitudinal cohorts.Frontiers in neurology · 2026Article
- The relationship between frailty and major adverse cardiovascular and cerebrovascular events in Chinese older adults: the mediating effect of lipid accumulation products.Archives of public health = Archives belges de sante publique · 2025Article
- Associations of Frailty Status and Sleep Quality With Incident Delirium: A Prospective Study in the UK Biobank.CNS neuroscience & therapeutics · 2025Article
- Cross-sectional association between hs-CRP/HDL-C ratio and physical frailty among middle-aged and older adults: findings from a population-based study.Frontiers in public health · 2025Article
- Assessment of frailty status in patients with acute cerebral infarction and their relationship with serum markers.American journal of translational research · 2024Article
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Abstract
introductionPrevious observational studies have found an increased risk of frailty in patients with stroke. However, evidence of a causal relationship between stroke and frailty is scarce. The aim of this study was to investigate the potential causal relationship between stroke and frailty index (FI).
methodsPooled data on stroke and debility were obtained from genome-wide association studies (GWAS).The MEGASTROKE Consortium provided data on stroke (N = 40,585), ischemic stroke (IS,N = 34,217), large-vessel atherosclerotic stroke (LAS,N = 4373), and cardioembolic stroke (CES,N = 7 193).Summary statistics for the FI were obtained from the most recent GWAS meta-analysis of UK BioBank participants and Swedish TwinGene participants of European ancestry (N = 175,226).Two-sample Mendelian randomization (MR) analyses were performed by inverse variance weighting (IVW), weighted median, MR-Egger regression, Simple mode, and Weighted mode, and heterogeneity and horizontal multiplicity of results were assessed using Cochran's Q test and MR-Egger regression intercept term test.
resultsThe results of the current MR study showed a significant correlation between stroke gene prediction and FI (odds ratio 1.104, 95% confidence interval 1.064 - 1.144, P < 0.001). In terms of stroke subtypes, IS (odds ratio 1.081, 95% confidence interval 1.044 - 1.120, P < 0.001) and LAS (odds ratio 1.037, 95% confidence interval 1.012 - 1.062, P = 0.005). There was no causal relationship between gene-predicted CES and FI. Horizontal multidimensionality was not found in the intercept test for MR Egger regression (P > 0.05), nor in the heterogeneity test (P > 0.05).
conclusionsThis study provides evidence for a causal relationship between stroke and FI and offers new insights into the genetic study of FI.
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