ArticleScientific reports2024
Tocilizumab is associated with reduced delirium and coma in critically ill patients with COVID-19.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Experimental model of ventilator-induced lung injury induces proteomic signatures of neurodegeneration in the hippocampus.Intensive care medicine experimental · 2026Article
- Current knowledge and challenges of sepsis-associated encephalopathy.Intensive care medicine · 2026Review
- A robust and scalable immunoadsorbent platform based on the high-affinity M03-IgG antibody for targeted IL-6 Removal in cytokine storm.Frontiers in immunology · 2026Article
- Antimicrobial treatment ameliorates delirium-like phenotypes in a murine model of urinary tract infection.Translational psychiatry · 2025Article
- The impact of autoimmune diseases on delirium risk in critically ill patients: a propensity score matching multicenter analysis.Frontiers in medicine · 2025Article
- The Pathophysiology and Biomarkers of Delirium.Seminars in neurology · 2024Review
- Microglia ameliorate delirium-like phenotypes in a murine model of acute ventilator-induced lung injury.Journal of neuroinflammation · 2024Article
- Comprehensive Review of COVID-19: Epidemiology, Pathogenesis, Advancement in Diagnostic and Detection Techniques, and Post-Pandemic Treatment Strategies.International journal of molecular sciences · 2024Review
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Authors and funding
7 authors.
Funding
Abstract
Recent preclinical studies demonstrate a direct pathological role for the interleukin-6 (IL-6) pathway in mediating structural and functional delirium-like phenotypes in animal models of acute lung injury. Tocilizumab, an IL-6 pathway inhibitor, has shown reduced duration of ventilator dependency and mortality in critically ill patients with COVID-19. In this study, we test the hypothesis that tocilizumab is associated with reduced delirium/coma prevalence in critically ill patients with COVID-19. 253 patients were included in the study cohort, 69 in the tocilizumab group and 184 in the historical control group who did not receive tocilizumab. Delirium was assessed using the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) with a positive score indicating delirium. Coma was defined as a Richmond Agitation-Sedation Scale score of - 4 or - 5. Tocilizumab was associated with significantly greater number of days alive without delirium/coma (tocilizumab [7 days (IQR: 3-9 days)] vs control [3 days (IQR: 1-8 days)]; p < 0.001). These results remained significant after adjusting for age, sex, sepsis, Charlson Comorbidity Index, Sequential Organ Failure Assessment score, and median daily dose of analgesics/sedatives (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.