ArticleNature2024
Kainate receptor channel opening and gating mechanism.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Pre-activation and gating pathway of AMPA receptors revealed by full and partial agonists.Nature structural & molecular biology · 2026Article
- Structural and mechanistic insights into gating and allosteric modulation of GluN1-GluN3A NMDA receptors.Nature structural & molecular biology · 2026Article
- The AMPA receptor life cycle: assembly, regulation and synaptic diversity.Nature reviews. Neuroscience · 2026Review
- Structures of partially occupied hetero-tetramers provide insight into kainate receptor activation and desensitization.Nature communications · 2026Article
- Mapping the evolution of kainate receptor research over five decades: trends, hotspots, and emerging frontiers.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Structural insights into kainate receptor desensitization.Nature communications · 2025Article
- Mechanistic snapshots of lipid-linked sugar transfer.Nature communications · 2025Article
- Article
- GluA4 AMPA receptor gating mechanisms and modulation by auxiliary proteins.Nature structural & molecular biology · 2025Article
- Activation of kainate receptor GluK2-Neto2 complex.Nature structural & molecular biology · 2025Article
- Article
- Article
- Cryo-EM snapshots of NMDA receptor activation illuminate sequential rearrangements.Science advances · 2025Article
- Atomistic mechanisms of calcium permeation modulated by Q/R editing and selectivity filter mutations in GluA2 AMPA receptors.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Structural basis of GluK2 kainate receptor activation by a partial agonist.Nature structural & molecular biology · 2025Article
- Positive AMPA and Kainate Receptor Modulators and Their Therapeutic Potential in CNS Diseases: A Comprehensive Review.International journal of molecular sciences · 2025Review
- Article
- Molecular Anatomy of Synaptic and Extrasynaptic Neurotransmission Between Nociceptive Primary Afferents and Spinal Dorsal Horn Neurons.International journal of molecular sciences · 2025Review
- Key regions aberrantly connected within cerebello-thalamo-cortical circuit and their genetic mechanism in schizophrenia: an fMRI meta-analysis and transcriptome study.Schizophrenia (Heidelberg, Germany) · 2025Review
- Reversal of anxiety-like depression induced by chronic corticosterone by crocin I and surface-enhanced Raman spectroscopy monitoring of plasma metabolites.Frontiers in pharmacology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Shanti Pal Gangwar *Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0003-1024-7608
Maria V Yelshanskaya *Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Kirill D Nadezhdin *Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0002-7140-0779
Laura Y YenDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Thomas P NewtonDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Muhammed AktolunDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID 0000-0002-2155-2977
Maria G KurnikovaDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID 0000-0002-8010-8374
Alexander I SobolevskyDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA. as4005@cumc.columbia.edu.ORCID 0000-0001-5181-8644
Funding
Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8MThe Stanford-SLAC CryoEM Center supplementU24GM129541 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH, HEDMAN, BRITT · 2018 to 2023
$54.8MNCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9MStructure and Function of AMPA subtype ionotropic glutamate receptorsR01NS083660 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KURNIKOVA, MARIA G, SOBOLEVSKY, ALEXANDER · 2013 to 2022
$4.3MTraining in Cellular, Molecular and Biomedical Studies (CMBS)T32GM145766 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Rebecca Anne Haeusler, RONALD K. LIEM · 2022 to 2026
$4.1MStructure and function of Transient Receptor Potential ChannelsR01CA206573 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2017 to 2026
$3.8MSingle-Particle Cryo-EM Characterization of AMPA Receptor Functional StatesR01NS107253 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2018 to 2026
$3.5MStructural and functional principles of activation and regulation of the transient receptor potential channel TRPV3.R01AR078814 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2022 to 2026
$2.8MStructure and Function of Ionotropic Glutamate ReceptorsR37NS083660 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2024 to 2026
$1.7MMolecular regulation of Kainate receptorsR21NS139087 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GANGWAR, SHANTI PAL · 2024 to 2024
$452kModulation of Heteromeric AMPA-Subtype iGluRs by Auxiliary SubunitsF31NS132554 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI YEN, LAURA YAUNHEE · 2024 to 2025
$105kNCI NIH HHS R01 CA206573NIAMS NIH HHS R01 AR078814NIGMS NIH HHS T32 GM145766NIGMS NIH HHS U24 GM129539NIGMS NIH HHS U24 GM129541NIGMS NIH HHS U24 GM129547NINDS NIH HHS F31 NS132554NINDS NIH HHS R01 NS083660NINDS NIH HHS R01 NS107253NINDS NIH HHS R21 NS139087NINDS NIH HHS R37 NS083660
Abstract
Kainate receptors, a subclass of ionotropic glutamate receptors, are tetrameric ligand-gated ion channels that mediate excitatory neurotransmission
Indexed as
GluK2 Kainate ReceptorGlutamic AcidIon Channel GatingAllosteric RegulationAnimalsConcanavalin ACryoelectron MicroscopyCyclic S-OxidesHumansLigandsModels, MolecularProtein DomainsRatsThiazinesBPAM344Concanavalin ACyclic S-OxidesGluK2 Kainate ReceptorGlutamic AcidLigandsThiazines
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.