Evidence map›Paper›PMID 38778158›Full record

ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2024

Resting state functional brain connectivity in child and adolescent psychiatry: where are we now?

Lucina Q Uddin, F Xavier Castellanos, Vinod Menon

Erratum issuedAbstract readReview
In one paragraph

Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Gestational PBDE concentrations and functional connectivity in adolescents: The HOME Study.International journal of hygiene and environmental health · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
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  15. Review
  16. Article
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  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Lucina Q UddinDepartment of Psychiatry and Biobehavioral Science, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA. lucina@ucla.edu.ORCID 0000-0003-2278-8962
F Xavier CastellanosDepartment of Child and Adolescent Psychiatry, New York University Grossman School of Medicine, New York, NY, USA.
Vinod MenonDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-1622-9857

Funding

Project-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5M
17/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UCLAU01DA050987 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUSAN Y BOOKHEIMER, Mirella Dapretto · 2020 to 2026
$9.0M
Circuit Mechanisms Governing the Default Mode NetworkR01MH126518 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Vinod Menon, Yen-Yu Ian Shih · 2021 to 2026
$4.3M
Integrative computational models of latent behavioral and neural constructs in children: a longitudinal developmental big-data approachR01MH121069 · NIMH · STANFORD UNIVERSITY · PI MENON, VINOD · 2019 to 2023
$3.9M
Exploratory investigation of bilingualism, executive function, and brain organization in children with autismR21HD111805 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI UDDIN, LUCINA QAZI · 2023 to 2023
$432k
NICHD NIH HHS R21 HD111805NIDA NIH HHS U01 DA050987NIMH NIH HHS R01 MH126518U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R21HD111805U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH121069U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH126518U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) UL1TR001445U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) U01DA050987
6 · The paper itself

Abstract

Approaching the 30th anniversary of the discovery of resting state functional magnetic resonance imaging (rsfMRI) functional connectivity, we reflect on the impact of this neuroimaging breakthrough on the field of child and adolescent psychiatry. The study of intrinsic functional brain architecture that rsfMRI affords across a wide range of ages and abilities has yielded numerous key insights. For example, we now know that many neurodevelopmental conditions are associated with more widespread circuit alterations across multiple large-scale brain networks than previously suspected. The emergence of population neuroscience and effective data-sharing initiatives have made large rsfMRI datasets publicly available, providing sufficient power to begin to identify brain-based subtypes within heterogeneous clinical conditions. Nevertheless, several methodological and theoretical challenges must still be addressed to fulfill the promises of personalized child and adolescent psychiatry. In particular, incomplete understanding of the physiological mechanisms driving developmental changes in intrinsic functional connectivity remains an obstacle to further progress. Future directions include cross-species and multimodal neuroimaging investigations to illuminate such mechanisms. Data collection and harmonization efforts that span multiple countries and diverse cohorts are urgently needed. Finally, incorporating naturalistic fMRI paradigms such as movie watching should be a priority for future research efforts.

Indexed as

BrainChild PsychiatryMagnetic Resonance ImagingAdolescentAdolescent PsychiatryBrain MappingChildHumansNerve NetNeural PathwaysRest

Identifiers

PMID38778158
PMCPMC11525794

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.