Evidence map›Paper›PMID 38778274›Full record

ArticleMolecular medicine (Cambridge, Mass.)2024

Effect of antibody-mediated connective tissue growth factor neutralization on lung edema in ventilator-induced lung injury in rats.

Charissa E van den Brom, Caitlin Bozic, Chantal A Polet, Annabel Bongers, Anita M Tuip-de Boer, Roselique Ibelings, Joris J T H Roelofs, Nicole P Juffermans

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine (Cambridge, Mass.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Charissa E van den BromDepartment of Anesthesiology, Amsterdam UMC, VU University, Amsterdam, The Netherlands. c.vandenbrom@amsterdamumc.nl.ORCID 0000-0002-0886-1388
Caitlin BozicDepartment of Anesthesiology, Amsterdam UMC, VU University, Amsterdam, The Netherlands.
Chantal A PoletLaboratory for Experimental Intensive Care and Anesthesiology (LEICA), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Annabel BongersLaboratory for Experimental Intensive Care and Anesthesiology (LEICA), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Anita M Tuip-de BoerLaboratory for Experimental Intensive Care and Anesthesiology (LEICA), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Roselique IbelingsDepartment of Anesthesiology, Amsterdam UMC, VU University, Amsterdam, The Netherlands.
Joris J T H RoelofsDepartment of Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Nicole P JuffermansLaboratory for Experimental Intensive Care and Anesthesiology (LEICA), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute respiratory distress syndrome (ARDS) is characterized by alveolar edema that can progress to septal fibrosis. Mechanical ventilation can augment lung injury, termed ventilator-induced lung injury (VILI). Connective tissue growth factor (CTGF), a mediator of fibrosis, is increased in ARDS patients. Blocking CTGF inhibits fibrosis and possibly vascular leakage. This study investigated whether neutralizing CTGF reduces pulmonary edema in VILI.

methodsFollowing LPS administration, rats were mechanically ventilated for 6 h with low (6 mL/kg; low V

resultsVILI was characterized by reduced PaO

conclusions'Double hit' VILI was characterized by inflammation, impaired oxygenation, pulmonary edema and histopathological lung injury. Blocking CTGF does not improve oxygenation nor reduce pulmonary edema in rats with VILI.

Indexed as

Connective Tissue Growth FactorPulmonary EdemaVentilator-Induced Lung InjuryAnimalsAntibodies, NeutralizingDisease Models, AnimalLungMaleRatsRats, Sprague-DawleyReceptor for Advanced Glycation End ProductsAntibodies, NeutralizingConnective Tissue Growth FactorReceptor for Advanced Glycation End ProductsARDSCTGFEdemaLungVentilator-induced lung injury

Identifiers

PMID38778274
PMCPMC11112940

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.