Evidence map›Paper›PMID 38778421›Full record

ArticleDiabetology & metabolic syndrome2024

Aged garlic extract preserves beta-cell functioning via modulation of nuclear factor kappa-B (NF-κB)/Toll-like receptor (TLR)-4 and sarco endoplasmic reticulum calcium ATPase (SERCA)/Ca

Sofi Imtiyaz Ali, Ahmed M E Elkhalifa, Showkat Ul Nabi, Faisal Sualeh Hayyat, Mehak Nazar, Syed Taifa, Rabia Rakhshan, Iqra Hussain Shah, Muzaffer Shaheen, Imtiyaz Ahmad Wani and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetology & metabolic syndrome, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Effects of aged black garlic (ABG10+Frontiers in nutrition · 2026
    Trial
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Sofi Imtiyaz AliPreclinical Research Laboratory, Department of Clinical Veterinary Medicine, Ethics and Jurisprudence, Faculty of Veterinary Sciences and Animal Husbandry, Sher-E-Kashmir University of Agricultural Sciences and Technology (SKUAST-Kashmir), Srinagar, Jammu and Kashmir, 190006, India.
Ahmed M E ElkhalifaDepartment of Public Health, College of Health Sciences, Saudi Electronic University, 11673, Riyadh, Saudi Arabia. a.alkhalifa@seu.edu.sa.
Showkat Ul NabiPreclinical Research Laboratory, Department of Clinical Veterinary Medicine, Ethics and Jurisprudence, Faculty of Veterinary Sciences and Animal Husbandry, Sher-E-Kashmir University of Agricultural Sciences and Technology (SKUAST-Kashmir), Srinagar, Jammu and Kashmir, 190006, India. showkatnabi@skuastkashmir.ac.in.
Faisal Sualeh HayyatSrinagar Women's College, Zakura, Srinagar, Jammu and Kashmir, 190024, India.
Mehak NazarPreclinical Research Laboratory, Department of Clinical Veterinary Medicine, Ethics and Jurisprudence, Faculty of Veterinary Sciences and Animal Husbandry, Sher-E-Kashmir University of Agricultural Sciences and Technology (SKUAST-Kashmir), Srinagar, Jammu and Kashmir, 190006, India.
Syed TaifaPreclinical Research Laboratory, Department of Clinical Veterinary Medicine, Ethics and Jurisprudence, Faculty of Veterinary Sciences and Animal Husbandry, Sher-E-Kashmir University of Agricultural Sciences and Technology (SKUAST-Kashmir), Srinagar, Jammu and Kashmir, 190006, India.
Rabia RakhshanDepartment of Clinical Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir, 190006, India.
Iqra Hussain ShahPreclinical Research Laboratory, Department of Clinical Veterinary Medicine, Ethics and Jurisprudence, Faculty of Veterinary Sciences and Animal Husbandry, Sher-E-Kashmir University of Agricultural Sciences and Technology (SKUAST-Kashmir), Srinagar, Jammu and Kashmir, 190006, India.
Muzaffer ShaheenPreclinical Research Laboratory, Department of Clinical Veterinary Medicine, Ethics and Jurisprudence, Faculty of Veterinary Sciences and Animal Husbandry, Sher-E-Kashmir University of Agricultural Sciences and Technology (SKUAST-Kashmir), Srinagar, Jammu and Kashmir, 190006, India.
Imtiyaz Ahmad WaniDepartment of Endocrinology and Clinical Research, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, 190002, India.
Umar MuzafferDepartment of Medicine, Govt. Medical College, Srinagar, Jammu and Kashmir, India.
Ovais Shabir ShahDepartment of Sheep Husbandry, Srinagar, Jammu and Kashmir, 190006, India.
Dil Mohammad MakhdoomiDirectorate of Extension, Sher-E-Kashmir University of Agricultural Sciences and Technology (SKUAST-Kashmir), Srinagar, Jammu and Kashmir, 190006, India.
Elsadig Mohamed AhmedDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Bisha, 61922, Bisha, Saudi Arabia.
Khalil A A KhalilDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Bisha, 61922, Bisha, Saudi Arabia.
Elsharif A BaziePediatric Department, Faculty of Medicine, University of El Imam El Mahdi, Kosti, 1158, Sudan.
Khalid Ibrahim ZawbaeeDepartment of Blood Bank, Autonomous University of Barcelona, Al-Ghad International College for Applied Sciences, 155166, Riyadh, Saudi Arabia.
Moataz Mohamed Al Hasan AliDepartment of Pathology, Faculty of Medicine, Al-Baha University, Al-Baha, Saudi Arabia.
Rakan J AlanaziDepartment of Pharmacy Practice, College of Pharmacy, Alfaisal University, 50927, Riyadh, Saudi Arabia.
Ibrahim Ali Al BatajMinistry of Health, Najran General Hospital, 66262, Najran, Saudi Arabia.
Saeed Musfar Al GahtaniDepartment of Blood Bank, College of Applied Medical Sciences, University of King Saud, 11433, Riyadh, Saudi Arabia.
Ali Jubran SalwiDepartment of Blood Bank, College of Applied Medical Sciences, University of King Saud, 11433, Riyadh, Saudi Arabia.
Lina Saeed AlrodanDepartment of Blood Bank, College of Applied Medical Sciences, University of King Saud, 11433, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeripheral insulin resistance and compromised insulin secretion from pancreatic β-cells are significant factors and pathogenic hallmarks of diabetes mellitus (DM). NF-κβ/TLR-4 and SERCA/Ca

methodsAGE was characterized by gas chromatography-mass spectrometry (GC-MS), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) to evaluate its physio-chemical characteristics followed by in-vitro anti-diabetic and antioxidant potential. This was followed by the induction of DM in laboratory animals for investigating the therapeutic action of AGE by evaluating the role of NF-κβ/TLR-4 and the SERCA/Ca

resultsAGE characterization by SEM, GC-MS, and X-ray diffraction (XRD) revealed the presence of phenylalanine, alliin, S-allylmercaptocysteine (SAMC), tryptophan, 1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid as major bioactive constituents of AGE. Metabolic studies, including intraperitoneal glucose tolerance test (IPGTT), revealed significantly lower blood glucose levels in the AGE group compared to the disease control group. In contrast, the intraperitoneal insulin tolerance test (ITT) exhibited no significant difference in insulin sensitivity between the AGE supplementation group and the DM control group. Interestingly, AGE was found to have no significant effect on fasting glucose and serum insulin levels. In contrast, AGE supplementation was found to cause significant hypoglycaemia in postprandial blood glucose and insulin levels. Importantly, AGE causes restoration of intracellular Ca

conclusionThe current study suggests that AGE enhance glucose homeostasis by exerting their effects on pancreatic β-cells, without ameliorating peripheral sensitivity. Moreover, AGEs promote an increase in β-cell mass by mitigating the apoptosis of pancreatic β-cells. These findings suggest that AGE could aid in developing a viable alternative therapy for diabetes mellitus (DM).

Indexed as

Aged garlic extractDiabetes mellitusNF-κB/TLR-4Pancreatic β-cellsSERCA/Ca2+Streptozotocin

Identifiers

PMID38778421
PMCPMC11110209

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.