Evidence map›Paper›PMID 38779828›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Association of cognitive reserve with transitions across cognitive states and death in older adults: A 15-year follow-up study.

Yuanjing Li, Serhiy Dekhtyar, Giulia Grande, Grégoria Kalpouzos, Caterina Gregorio, Erika J Laukka, Chengxuan Qiu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuanjing LiAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University, Solna, Sweden.ORCID 0000-0002-1525-5538
Serhiy DekhtyarAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University, Solna, Sweden.
Giulia GrandeAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University, Solna, Sweden.
Grégoria KalpouzosAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University, Solna, Sweden.
Caterina GregorioBiostatistics Unit, Department of Medical Sciences, University of Trieste, Trieste TS, Italy.
Erika J LaukkaAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University, Solna, Sweden.
Chengxuan QiuAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet-Stockholm University, Solna, Sweden.

Funding

China Scholarship Council 201906220042Karolinska Institutet 2018-01854Karolinska Institutet 2020-01456Swedish Foundation for International Cooperation in Research and Higher Education CH2019-8320Swedish Research Council 2017-05819Swedish Research Council 2017-06088Swedish Research Council 2020-01030Swedish Research Council 2020-01574Swedish Research Council 2021-02338Swedish Research Council 2021-06502Swedish Research Council 2022-06332.Swedish Research Council for Health, Working Life and Welfare 2016-07175Swedish Research Council for Health, Working Life and Welfare 2019-01076.
6 · The paper itself

Abstract

introductionWe investigated the association of cognitive reserve (CR) with transitions across cognitive states and death.

methodsThis population-based cohort study included 2631 participants (age ≥60 years) who were dementia-free at baseline and regularly examined up to 15 years. Data were analyzed using the Markov multistate models.

resultsEach 1-point increase in the composite CR score (range: -4.25 to 3.46) was significantly associated with lower risks of transition from normal cognition to cognitive impairment, no dementia (CIND) (multivariable-adjusted hazards ratio = 0.78; 95% confidence interval = 0.72-0.85) and death (0.85; 0.79-0.93), and from CIND to death (0.82; 0.73-0.91), but not from CIND to normal cognition or dementia. A greater composite CR score was associated with a lower risk of transition from CIND to death in people aged 60-72 but not in those aged ≥ 78 years. DISCUSSION: CR contributes to cognitive health by delaying cognitive deterioration in the prodromal phase of dementia. HIGHLIGHTS: We use Markov multistate model to examine the association between cognitive reserve and transitions across cognitive states and death. A great cognitive reserve contributes to cognitive health by delaying cognitive deterioration in the prodromal phase of dementia. A great cognitive reserve is associated with a lower risk of transition from cognitive impairment, no dementia to death in people at the early stage of old age, but not in those at the late stage of old age.

Indexed as

Cognitive DysfunctionCognitive ReserveAgedAged, 80 and overCognitionCohort StudiesDementiaDisease ProgressionFemaleFollow-Up StudiesHumansMaleMarkov ChainsMiddle AgedNeuropsychological TestsCohort studyDementiaLifelong cognitive reserveMild cognitive impairmentPathological brain aging

Identifiers

PMID38779828
PMCPMC11247709

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.