Evidence map›Paper›PMID 38780480›Full record

ArticleStatistical methods in medical research2024

Demystifying estimands in cluster-randomised trials.

Brennan C Kahan, Bryan S Blette, Michael O Harhay, Scott D Halpern, Vipul Jairath, Andrew Copas, Fan Li

Abstract read
In one paragraph

Article in Statistical methods in medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Trial
  2. Article
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  5. Model-robust standardization in stepped wedge cluster randomized trials.Journal of the Royal Statistical Society. Series A, (Statistics in Society) · 2026
    Article
  6. Article
  7. Article
  8. Use of estimands in cluster randomised trials: A review.Clinical trials (London, England) · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Multilevel Intervention Stepped Wedge Designs (MLI-SWDs).Prevention science : the official journal of the Society for Prevention Research · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brennan C KahanMRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, UCL, London, UK.ORCID 0000-0001-9957-0844
Bryan S BletteDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, USA.ORCID 0000-0002-3121-7718
Michael O HarhayMRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, UCL, London, UK.
Scott D HalpernDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Vipul JairathDepartment of Medicine, Division of Gastroenterology, Schulich School of Medicine, Western University, London, ON, Canada.
Andrew CopasMRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, UCL, London, UK.
Fan LiDepartment of Biostatistics, Yale University School of Public Health, New Haven, CT, USA.ORCID 0000-0001-6183-1893

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Improving the measurement and analysis of long-term, patient-centered outcomes following acute respiratory failureR00HL141678 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI HARHAY, MICHAEL OSCAR · 2020 to 2022
$747k
Medical Research CouncilNCATS NIH HHS UL1 TR001863NHLBI NIH HHS R00 HL141678
6 · The paper itself

Abstract

Estimands can help clarify the interpretation of treatment effects and ensure that estimators are aligned with the study's objectives. Cluster-randomised trials require additional attributes to be defined within the estimand compared to individually randomised trials, including whether treatment effects are

Indexed as

Randomized Controlled Trials as TopicCluster AnalysisData Interpretation, StatisticalHumansModels, Statisticalanalysis of cluster-level summariescluster-averagecluster-randomised trialcluster-specificEstimandindependence estimating equationsmarginalparticipant-average

Identifiers

PMID38780480
PMCPMC11348634

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.