Evidence map›Paper›PMID 38786663›Full record

ArticleJournal of fungi (Basel, Switzerland)2024

Impact of Nitric Oxide-Release Kinetics on Antifungal Activity.

Quincy E Grayton, Ivie L Conlon, Christopher A Broberg, Mark H Schoenfisch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Quincy E GraytonDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-9381-8551
Ivie L ConlonDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Christopher A BrobergDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Mark H SchoenfischDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-2212-0658

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
North Carolina Translational and Clinical Science Institute (NC TraCS) TL1TL1TR002491 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROY-CHAUDHURY, PRABIR · 2018 to 2022
$1.5M
Nitric oxide-releasing glycosaminoglycans for treating complex woundsR01DK132778 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark H Schoenfisch, Shannon Margaret Wallet · 2023 to 2026
$1.5M
Andor Dragonfly 202 Spinning Disk Confocal Microscope for the University of North Carolina at Chapel HillS10OD030223 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ARIEL, PABLO · 2021 to 2021
$474k
NCATS NIH HHS TL1 TR002491NCI NIH HHS P30 CA016086NIDDK NIH HHS R01 DK132778NIH HHS DK132778NIH HHS S10 OD030223
6 · The paper itself

Abstract

Pathogenic fungi are an increasing health threat due to the rise in drug resistance. The limited number of antifungals currently available and growing incidence of multi-drug-resistant fungi has caused rising healthcare costs and a decreased quality of life for patients with fungal infections. Nitric oxide (NO) has previously been shown to act as an antimicrobial agent, albeit with a limited understanding of the effects of the NO-release kinetics against pathogenic fungi. Herein, the antifungal effects of four nitric oxide-releasing small molecules were studied against the pathogenic fungi

Indexed as

antifungalAspergillus fumigatusCandida albicansCandida aurisCryptococcus neoformansnitric oxide

Identifiers

PMID38786663
PMCPMC11121837

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.