ArticleAmerican journal of physiology. Heart and circulatory physiology2024
Innervation of adipocytes is limited in mouse perivascular adipose tissue.
Article in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Three-dimensional mapping and functional analysis of sympathetic innervation in aortic perivascular adipose tissue.Life metabolism · 2026Article
- Connexin-43-Mediated Gap Junction Coupling Between Adipocytes Regulates Norepinephrine-Induced CaCells · 2026Article
- Sex-Specific Characteristics of Perivascular Fat in Aortic Aneurysms.Journal of clinical medicine · 2025Review
- The neuro-immune axis in cancer: mechanisms of innervation-driven tumor progression and therapeutic opportunities.Frontiers in immunology · 2025Review
- Sympathetic nerves are sparsely distributed in rat mesenteric perivascular adipose tissue.Frontiers in physiology · 2025Article
- Perivascular adipose tissue: a central player in the triad of diabetes, obesity, and cardiovascular health.Cardiovascular diabetology · 2024Review
- Phenotypic and functional disparities in perivascular adipose tissue.Frontiers in physiology · 2024Review
- Rat perivascular adipose tissue microvasculature revealed by tissue clearing.Frontiers in physiology · 2024Article
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5 authors.
Funding
Abstract
Perivascular adipose tissue (PVAT) regulates vascular tone by releasing anticontractile factors. These anticontractile factors are driven by processes downstream of adipocyte stimulation by norepinephrine; however, whether norepinephrine originates from neural innervation or other sources is unknown. The goal of this study was to test the hypothesis that neurons innervating PVAT provide the adrenergic drive to stimulate adipocytes in aortic and mesenteric perivascular adipose tissue (aPVAT and mPVAT), and white adipose tissue (WAT). Healthy male and female mice (8-13 wk) were used in all experiments. Expression of genes associated with synaptic transmission were quantified by qPCR and adipocyte activity in response to neurotransmitters and neuron depolarization was assessed in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.