Evidence map›Paper›PMID 38787724›Full record

ArticleCell reports2024

Hypnotic treatment improves sleep architecture and EEG disruptions and rescues memory deficits in a mouse model of fragile X syndrome.

Jessy D Martinez, Lydia G Wilson, William P Brancaleone, Kathryn G Peterson, Donald S Popke, Valentina Caicedo Garzon, Roxanne E Perez Tremble, Marcus J Donnelly, Stephany L Mendez Ortega, Daniel Torres and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jessy D MartinezDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Lydia G WilsonDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
William P BrancaleoneUndergraduate Program in Neuroscience, University of Michigan, Ann Arbor, MI 48109, USA.
Kathryn G PetersonUndergraduate Program in Neuroscience, University of Michigan, Ann Arbor, MI 48109, USA.
Donald S PopkeUndergraduate Program in Neuroscience, University of Michigan, Ann Arbor, MI 48109, USA.
Valentina Caicedo GarzonDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Roxanne E Perez TrembleDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Marcus J DonnellyUndergraduate Program in Neuroscience, University of Michigan, Ann Arbor, MI 48109, USA.
Stephany L Mendez OrtegaUndergraduate Program in Neuroscience, University of Michigan, Ann Arbor, MI 48109, USA.
Daniel TorresDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
James J ShaverDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Sha JiangDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Zhongying YangDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Sara J AtonDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: saton@umich.edu.

Funding

Linking network activity and intracellular plasticity mechanisms during sleep-depDP2MH104119 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ATON, SARA J · 2013 to 2013
$2.3M
Thalamocortical and corticocortical mechanisms for sleep-dependent visual learningR01NS104776 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ATON, SARA J · 2018 to 2022
$1.9M
Linking interneuron-mediated circuit regulation with sleep-dependent plasticity and memory storage in the hippocampusRF1NS118440 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ATON, SARA J · 2020 to 2020
$1.4M
Linking interneuron-mediated circuit regulation with sleep-dependent plasticity and memory storage in the hippocampusR01NS118440 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ATON, SARA J · 2023 to 2024
$880k
NIMH NIH HHS DP2 MH104119NINDS NIH HHS R01 NS104776NINDS NIH HHS R01 NS118440NINDS NIH HHS RF1 NS118440
6 · The paper itself

Abstract

Fragile X syndrome (FXS) is associated with disrupted cognition and sleep abnormalities. Sleep loss negatively impacts cognitive function, and one untested possibility is that disrupted cognition in FXS is exacerbated by abnormal sleep. We tested whether ML297, a hypnotic acting on G-protein-activated inward-rectifying potassium (GIRK) channels, could reverse sleep phenotypes and disrupted memory in Fmr1

Indexed as

Disease Models, AnimalElectroencephalographyFragile X Messenger Ribonucleoprotein 1Fragile X SyndromeMemory DisordersSleepAnimalsFearHippocampusHypnotics and SedativesMaleMemory ConsolidationMiceMice, Inbred C57BLFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1Hypnotics and SedativesCP: Neuroscienceexcitation-inhibition balanceFmr1Fragile X syndromehippocampusneurodevelopmental disordersNREM sleepparvalbumin-expressing interneuronREM sleepsleep

Identifiers

PMID38787724
PMCPMC11910971

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.