Evidence map›Paper›PMID 38788790›Full record

ArticleEnvironmental research2024

Organophosphate pesticide exposure and risk of SARS-CoV-2 infection.

Luis Lopez, Katie Kogut, Stephen Rauch, Robert B Gunier, Marcus P Wong, Eva Harris, Julianna Deardorff, Brenda Eskenazi, Kim G Harley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luis LopezDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, United States.
Katie KogutCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, United States.
Stephen RauchCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, United States.
Robert B GunierCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, United States.
Marcus P WongDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, United States.
Eva HarrisDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, United States.
Julianna DeardorffCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, United States.
Brenda EskenaziCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, United States.
Kim G HarleyCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, United States. Electronic address: kharley@berkeley.edu.

Funding

Project C: Epigenetic Effects of DDT/E and PBDEs on PubertyP01ES009605 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 1999 to 2015
$11.2M
Effect of early life exposure to social adversity and pesticides on risk-taking behavior of 16-18 year olds: the CHAMACOS studyR01ES026994 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 2016 to 2020
$3.9M
Fostering Scientific and Workforce Diversity by Maintaining and Enriching the CHAMACOS Birth CohortU24ES028529 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI GUNIER, ROBERT · 2023 to 2025
$1.1M
NIEHS NIH HHS P01 ES009605NIEHS NIH HHS R01 ES026994NIEHS NIH HHS U24 ES028529
6 · The paper itself

Abstract

Several studies have reported immune modulation by organophosphate (OP) pesticides, but the relationship between OP exposure and SARS-CoV-2 infection is yet to be studied. We used two different measures of OP pesticide exposure (urinary biomarkers (N = 154) and residential proximity to OP applications (N = 292)) to examine the association of early-childhood and lifetime exposure to OPs and risk of infection of SARS-CoV-2 using antibody data. Our study population consisted of young adults (ages 18-21 years) from the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) Study, a longitudinal cohort of families from a California agricultural region. Urinary biomarkers reflected exposure from in utero to age 5 years. Residential proximity reflected exposures between in utero and age 16 years. SARS-CoV-2 antibodies in blood samples collected between June 2022 and January 2023 were detected via two enzyme linked immunosorbent assays, each designed to bind to different SARS-CoV-2 antigens. We performed logistic regression for each measure of pesticide exposure, adjusting for covariates from demographic data and self-reported questionnaire data. We found increased odds of SARS-CoV-2 infection among participants with higher urinary biomarkers of OPs in utero (OR = 1.94, 95% CI: 0.71, 5,58) and from age 0-5 (OR = 1.90, 95% CI: 0.54, 6.95).

Indexed as

COVID-19Environmental ExposurePesticidesSARS-CoV-2AdolescentAdultAntibodies, ViralBiomarkersCaliforniaFemaleHumansLongitudinal StudiesMaleOrganophosphatesPregnancyYoung AdultAntibodies, ViralBiomarkersOrganophosphatesPesticidesImmune systemLong-term exposureOrganophosphate pesticidesSARS-CoV-2

Identifiers

PMID38788790
PMCPMC11614353

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.