Evidence map›Paper›PMID 38790607›Full record

ArticleAntioxidants (Basel, Switzerland)2024

Ginger Polyphenols Reverse Molecular Signature of Amygdala Neuroimmune Signaling and Modulate Microbiome in Male Rats with Neuropathic Pain: Evidence for Microbiota-Gut-Brain Axis.

Chwan-Li Shen, Julianna Maria Santos, Moamen M Elmassry, Viren Bhakta, Zarek Driver, Guangchen Ji, Vadim Yakhnitsa, Takaki Kiritoshi, Jacob Lovett, Abdul Naji Hamood and 2 more

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chwan-Li ShenDepartment of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.ORCID 0000-0001-9595-6598
Julianna Maria SantosDepartment of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Moamen M ElmassryDepartment of Molecular Biology, Princeton University, Princeton, NJ 08540, USA.
Viren BhaktaDepartment of Biology, Texas Tech University, Lubbock, TX 79401, USA.
Zarek DriverDepartment of Biochemistry, Texas Tech University, Lubbock, TX 79401, USA.
Guangchen JiDepartment of Pharmacology & Neuroscience, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Vadim YakhnitsaDepartment of Pharmacology & Neuroscience, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Takaki KiritoshiDepartment of Pharmacology & Neuroscience, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.ORCID 0000-0002-5297-3379
Jacob LovettDepartment of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Abdul Naji HamoodDepartment of Microbiology and Infectious Disease, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.ORCID 0000-0001-7193-7827
Shengmin SangLaboratory for Functional Foods and Human Health, Center for Excellence in Post Harvest Technologies, North Carolina A&T State University, North Carolina Research Campus, Kannapolis, NC 28081, USA.ORCID 0000-0002-5005-3616
Volker NeugebauerCenter of Excellence for Integrative Health, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

Funding

PAIN, NOCICEPTION, AND THE AMYGDALAR01NS038261 · NINDS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI Volker Neugebauer, Igor Ponomarev · 1999 to 2026
$8.7M
NINDS NIH HHS R01 NS038261USDA/NIFA 2021-67017-34026
6 · The paper itself

Abstract

Emerging evidence shows that the gut microbiota plays an important role in neuropathic pain (NP) via the gut-brain axis. Male rats were divided into sham, spinal nerve ligation (SNL), SNL + 200 mg GEG/kg BW (GEG200), and SNL + 600 mg GEG/kg BW (GEG600) for 5 weeks. The dosages of 200 and 600 mg GEG/kg BW for rats correspond to 45 g and 135 g raw ginger for human daily consumption, respectively. Both GEG groups mitigated SNL-induced NP behavior. GEG-supplemented animals had a decreased abundance of

Indexed as

braingingergut microbiomeneuroinflammationpain

Identifiers

PMID38790607
PMCPMC11118883

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.