Evidence map›Paper›PMID 38791257›Full record

ArticleInternational journal of molecular sciences2024

Challenges of Robust RNAi-Mediated Gene Silencing in

Lucas Henrique Figueiredo Prates, Jakob Fiebig, Henrik Schlosser, Eleni Liapi, Tanja Rehling, Célia Lutrat, Jeremy Bouyer, Qiang Sun, Han Wen, Zhiyong Xi and 2 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. EngineeredInsects · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. ExploitingPathogens (Basel, Switzerland) · 2025
    Review
  8. Identification of a dengue 2 virus envelope protein receptor inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lucas Henrique Figueiredo PratesDepartment of Insect Biotechnology in Plant Protection, Justus Liebig University Giessen, 35394 Giessen, Germany.ORCID 0000-0003-0739-5597
Jakob FiebigDepartment of Insect Biotechnology in Plant Protection, Justus Liebig University Giessen, 35394 Giessen, Germany.
Henrik SchlosserDepartment of Insect Biotechnology in Plant Protection, Justus Liebig University Giessen, 35394 Giessen, Germany.ORCID 0009-0009-1217-0692
Eleni LiapiDepartment of Biochemistry and Biotechnology, University of Thessaly, 41500 Larissa, Greece.ORCID 0009-0000-7175-8618
Tanja RehlingDepartment of Insect Biotechnology in Plant Protection, Justus Liebig University Giessen, 35394 Giessen, Germany.ORCID 0000-0003-4173-9816
Célia LutratASTRE, CIRAD, 34398 Montpellier, France.ORCID 0000-0003-3440-8939
Jeremy BouyerASTRE, CIRAD, 34398 Montpellier, France.ORCID 0000-0002-1913-416X
Qiang SunDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.
Han WenDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0003-1820-3220
Zhiyong XiDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0001-7786-012X
Marc F ScheteligDepartment of Insect Biotechnology in Plant Protection, Justus Liebig University Giessen, 35394 Giessen, Germany.ORCID 0000-0002-9217-394X
Irina HäckerDepartment of Insect Biotechnology in Plant Protection, Justus Liebig University Giessen, 35394 Giessen, Germany.ORCID 0000-0003-4022-4853

Funding

German Academic Exchange Service 57507871
6 · The paper itself

Abstract

In this study, we report the complexities and challenges associated with achieving robust RNA interference (RNAi)-mediated gene knockdown in the mosquitoes

Indexed as

AedesRNA InterferenceAnimalsGene Knockdown TechniquesGene SilencingLarvaMosquito VectorsRNA, Double-StrandedRNA, Small InterferingRNA, Double-StrandedRNA, Small InterferingAedes aegyptiAedes albopictusreproducibility of RNAi protocolsRNAi-based pest controlRNAi delivery methodsRNA interference

Identifiers

PMID38791257
PMCPMC11121262

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.