Evidence map›Paper›PMID 38791296›Full record

ArticleInternational journal of molecular sciences2024

Genome-Wide Epistatic Network Analyses of Semantic Fluency in Older Adults.

Qihua Tan, Weilong Li, Marianne Nygaard, Ping An, Mary Feitosa, Mary K Wojczynski, Joseph Zmuda, Konstantin Arbeev, Svetlana Ukraintseva, Anatoliy Yashin and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qihua TanEpidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, 5230 Odense, Denmark.ORCID 0000-0003-3194-0030
Weilong LiEpidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, 5230 Odense, Denmark.ORCID 0000-0001-9448-7953
Marianne NygaardEpidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, 5230 Odense, Denmark.ORCID 0000-0003-0703-2665
Ping AnDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Mary FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-0933-2410
Mary K WojczynskiDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Joseph ZmudaDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Konstantin ArbeevBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NA 27708, USA.ORCID 0000-0002-4195-7832
Svetlana UkraintsevaBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NA 27708, USA.ORCID 0000-0002-0079-5494
Anatoliy YashinBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NA 27708, USA.
Kaare ChristensenEpidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, 5230 Odense, Denmark.ORCID 0000-0002-5429-5292
Jonas Mengel-FromEpidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, 5230 Odense, Denmark.ORCID 0000-0003-1573-8908

Funding

The Long Life Family StudyU19AG063893 · NIA · WASHINGTON UNIVERSITY · PI PAOLA SEBASTIANI · 2019 to 2026
$125.4M
NIA NIH HHS U19 AG063893NIH/NIA U19AG063893
6 · The paper itself

Abstract

Semantic fluency impairment has been attributed to a wide range of neurocognitive and psychiatric conditions, especially in the older population. Moderate heritability estimates on semantic fluency were obtained from both twin and family-based studies suggesting genetic contributions to the observed variation across individuals. Currently, effort in identifying the genetic variants underlying the heritability estimates for this complex trait remains scarce. Using the semantic fluency scale and genome-wide SNP genotype data from the Long Life Family Study (LLFS), we performed a genome-wide association study (GWAS) and epistasis network analysis on semantic fluency in 2289 individuals aged over 60 years from the American LLFS cohorts and replicated the findings in 1129 individuals aged over 50 years from the Danish LLFS cohort. In the GWAS, two SNPs with genome-wide significance (rs3749683,

Indexed as

Epistasis, GeneticGenome-Wide Association StudyPolymorphism, Single NucleotideAgedAged, 80 and overFemaleGene Regulatory NetworksGenotypeHumansMaleMiddle AgedSemanticselderlyepistasisGWASLLFSsemantic fluency

Identifiers

PMID38791296
PMCPMC11120839

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.