Evidence map›Paper›PMID 38793554›Full record

ArticleViruses2024

Longitudinal Dynamics of Immune Response in Occupational Populations Post COVID-19 Infection in the Changning District of Shanghai, China.

Li Li, Fengge Wang, Xiaoding He, Tingting Pei, Jiani Lu, Zhan Zhang, Ping Zhao, Jiayu Xue, Lin Zhu, Xinxin Chen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Li LiShanghai Changning Center for Disease Control and Prevention, 39 Yunwushan Road, Shanghai 200051, China.ORCID 0009-0002-7257-3222
Fengge WangShanghai Institute of Infectious Disease and Biosecurity, Fudan University, 130 Dong'an Road, Shanghai 200032, China.
Xiaoding HeShanghai Changning Center for Disease Control and Prevention, 39 Yunwushan Road, Shanghai 200051, China.
Tingting PeiShanghai Changning Center for Disease Control and Prevention, 39 Yunwushan Road, Shanghai 200051, China.
Jiani LuShanghai Changning Center for Disease Control and Prevention, 39 Yunwushan Road, Shanghai 200051, China.
Zhan ZhangShanghai Changning Center for Disease Control and Prevention, 39 Yunwushan Road, Shanghai 200051, China.
Ping ZhaoShanghai Changning Center for Disease Control and Prevention, 39 Yunwushan Road, Shanghai 200051, China.
Jiayu XueShanghai Changning Center for Disease Control and Prevention, 39 Yunwushan Road, Shanghai 200051, China.
Lin ZhuShanghai Changning Center for Disease Control and Prevention, 39 Yunwushan Road, Shanghai 200051, China.
Xinxin ChenShanghai Changning Center for Disease Control and Prevention, 39 Yunwushan Road, Shanghai 200051, China.
Zijie YanShanghai Changning Center for Disease Control and Prevention, 39 Yunwushan Road, Shanghai 200051, China.
Yihan LuShanghai Institute of Infectious Disease and Biosecurity, Fudan University, 130 Dong'an Road, Shanghai 200032, China.ORCID 0000-0003-4651-9433
Jianlin ZhuangShanghai Changning Center for Disease Control and Prevention, 39 Yunwushan Road, Shanghai 200051, China.

Funding

Changning District Acute Infectious Disease Prevention Doctoral and Postdoctoral Innovative Talent Base in Shanghai, China RCJD2022S09
6 · The paper itself

Abstract

Monitoring the long-term changes in antibody and cellular immunity following Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is crucial for understanding immune mechanisms that prevent reinfection. In March 2023, we recruited 167 participants from the Changning District, Shanghai, China. A subset of 66 participants that were infected between November 2022 and January 2023 was selected for longitudinal follow-up. The study aimed to investigate the dynamics of the immune response, including neutralizing antibodies (NAbs), anti-spike (S)-immunoglobulin G (IgG), anti-S-IgM, and lymphocyte profiles, by analyzing peripheral blood samples collected three to seven months post infection. A gradual decrease in NAbs and IgG levels were observed from three to seven months post infection. No significant differences in NAbs and IgG titers were found across various demographics, including age, sex, occupation, and symptomatic presentation, across five follow-up assessments. Additionally, a strong correlation between NAbs and IgG levels was identified. Lymphocyte profiles showed a slight change at five months but had returned to baseline levels by seven months post infection. Notably, healthcare workers exhibited lower B-cell levels compared to police officers. Our study demonstrated that the immune response to SARS-CoV-2 infection persisted for at least seven months. Similar patterns in the dynamics of antibody responses and cellular immunity were observed throughout this period.

Indexed as

Antibodies, NeutralizingAntibodies, ViralCOVID-19Immunoglobulin GSARS-CoV-2AdultChinaFemaleHealth PersonnelHumansImmunity, CellularImmunoglobulin MLongitudinal StudiesMaleMiddle AgedSpike Glycoprotein, CoronavirusAntibodies, NeutralizingAntibodies, ViralImmunoglobulin GImmunoglobulin MSpike Glycoprotein, Coronavirusantibodycellular immunitydynamic changesoccupational populationSARS-CoV-2

Identifiers

PMID38793554
PMCPMC11125686

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.