Evidence map›Paper›PMID 38794462›Full record

ArticlePlants (Basel, Switzerland)2024

CRISPR/Cas9-Mediated Knockout of the Lycopene ε-Cyclase for Efficient Astaxanthin Production in the Green Microalga

Jacob Sebastian Kneip, Niklas Kniepkamp, Junhwan Jang, Maria Grazia Mortaro, EonSeon Jin, Olaf Kruse, Thomas Baier

Abstract read
In one paragraph

Article in Plants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. CRISPR-Cas Technology TurnsMarine drugs · 2025
    Review
  10. Review
  11. Harnessing microalgae for bioproducts: innovations in synthetic biology.World journal of microbiology & biotechnology · 2025
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. EngineeredLife (Basel, Switzerland) · 2025
    Article
  17. Review
  18. Progress and challenges in CRISPR/Cas applications in microalgae.Journal of microbiology (Seoul, Korea) · 2025
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jacob Sebastian KneipAlgae Biotechnology and Bioenergy, Faculty of Biology, Center for Biotechnology (CeBiTec), Bielefeld University, 33615 Bielefeld, Germany.ORCID 0000-0001-7384-5934
Niklas KniepkampAlgae Biotechnology and Bioenergy, Faculty of Biology, Center for Biotechnology (CeBiTec), Bielefeld University, 33615 Bielefeld, Germany.
Junhwan JangDepartment of Life Science, Research Institute for Natural Sciences, Hanyang University, Seoul 04763, Republic of Korea.ORCID 0000-0002-2550-6708
Maria Grazia MortaroAlgae Biotechnology and Bioenergy, Faculty of Biology, Center for Biotechnology (CeBiTec), Bielefeld University, 33615 Bielefeld, Germany.ORCID 0009-0002-2955-0519
EonSeon JinDepartment of Life Science, Research Institute for Natural Sciences, Hanyang University, Seoul 04763, Republic of Korea.ORCID 0000-0001-5691-0124
Olaf KruseAlgae Biotechnology and Bioenergy, Faculty of Biology, Center for Biotechnology (CeBiTec), Bielefeld University, 33615 Bielefeld, Germany.ORCID 0000-0001-9874-382X
Thomas BaierAlgae Biotechnology and Bioenergy, Faculty of Biology, Center for Biotechnology (CeBiTec), Bielefeld University, 33615 Bielefeld, Germany.ORCID 0000-0002-5226-3035

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carotenoids are valuable pigments naturally occurring in all photosynthetic plants and microalgae as well as in selected fungi, bacteria, and archaea. Green microalgae developed a complex carotenoid profile suitable for efficient light harvesting and light protection and harbor great capacity for carotenoid production through the substantial power of the endogenous 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Previous works established successful genome editing and induced significant changes in the cellular carotenoid content in

Indexed as

astaxanthin productionChlamydomonas reinhardtiigenome editinglycopene ß-cyclaselycopene ε-cyclasemetabolic engineeringmicroalgal carotenoids

Identifiers

PMID38794462
PMCPMC11125023

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.