ArticleNutrients2024
The Inverted U-Shaped Association between Serum Vitamin D and Serum Uric Acid Status in Children and Adolescents: A Large Cross-Sectional and Longitudinal Analysis.
Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Recent advances in research on the association between paediatric hyperuricaemia and bone health.Frontiers in endocrinology · 2026Pooled it
- Pediatric hyperuricemia: genetic basis, metabolic mechanisms, and clinical implications.Frontiers in endocrinology · 2026Review
- Association between serum vitamin D levels and cardiovascular disease risk in patients with hyperuricemia: A cross-sectional study.PloS one · 2026Article
- Association between vitamin D and serum uric acid in a large Chinese cohort of middle-aged and elderly Chinese men and women.Frontiers in nutrition · 2026Article
- Non-Linear Associations Between Serum Vitamin D and Uric Acid in Korean Adults: 2022-2023 KNHANES Data.Nutrients · 2025Article
- Review
- Cross-sectional and longitudinal associations between serum vitamin D and continuous metabolic syndrome score among children and adolescents: roles of levels of inflammation in peripheral blood.Nutrition & metabolism · 2025Article
- Vitamin D nutritional status and the influencing factors among children and adolescents.Frontiers in public health · 2025Article
- Association between 25 hydroxyvitamin D and serum uric acid level in the Chinese general population: a cross-sectional study.BMC endocrine disorders · 2024Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundSerum vitamin D is associated with hyperuricemia. However, previous studies have been controversial, with limited focus on children and adolescents.
objectiveThis study aimed to examine the cross-sectional and longitudinal associations between serum vitamin D and serum uric acid (SUA) levels in children and adolescents.
methodsThe cross-sectional survey comprised 4777 participants aged 6 to 18 years, while the longitudinal survey involved 1641 participants aged 6 to 12 years, all derived from an ongoing cohort study in Shenzhen, China. Restricted cubic splines were used to visualize the dose-response relationship between vitamin D and SUA and the risk of higher SUA status. Two-segment generalized linear models (GLM) and logistic models were used to assess the association between vitamin D and SUA and higher SUA status, respectively. The longitudinal analysis used GLM.
resultsWe observed an inverted U-shaped relationship between vitamin D and SUA (
conclusionsAn inverse U-shaped relationship was observed between vitamin D and SUA as well as the risk of higher SUA status. Sufficient vitamin D levels appear to play a preventative role against the age-related increase in SUA. Ensuring adequate vitamin D levels may be beneficial in improving uric acid metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.