Evidence map›Paper›PMID 38794746›Full record

ArticleNutrients2024

RETRACTED: Involvement of GPR43 Receptor in Effect of

Ana Karolina Sá, Fabiana Olímpio, Jessica Vasconcelos, Paloma Rosa, Hugo Caire Faria Neto, Carlos Rocha, Maurício Frota Camacho, Uilla Barcick, Andre Zelanis, Flavio Aimbire

RetractedAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Ana Karolina SáDepartment of Medicine, Postgraduate Program in Translational Medicine, Federal University of São Paulo (UNIFESP), Rua Pedro De Toledo 720-2 Andar, Vila Clementino, São Paulo 04039-002, Brazil.ORCID 0000-0001-5911-4510
Fabiana OlímpioDepartment of Medicine, Postgraduate Program in Translational Medicine, Federal University of São Paulo (UNIFESP), Rua Pedro De Toledo 720-2 Andar, Vila Clementino, São Paulo 04039-002, Brazil.ORCID 0000-0002-7590-3904
Jessica VasconcelosDepartment of Medicine, Postgraduate Program in Translational Medicine, Federal University of São Paulo (UNIFESP), Rua Pedro De Toledo 720-2 Andar, Vila Clementino, São Paulo 04039-002, Brazil.ORCID 0000-0001-8011-9965
Paloma RosaDepartment of Medicine, Postgraduate Program in Translational Medicine, Federal University of São Paulo (UNIFESP), Rua Pedro De Toledo 720-2 Andar, Vila Clementino, São Paulo 04039-002, Brazil.ORCID 0000-0001-7560-056X
Hugo Caire Faria NetoLaboratory of Immunopharmacology, Oswaldo Cruz Foundation Fundação Oswaldo Cruz, Av. Brazil, Rio de Janeiro 4036, Brazil.ORCID 0000-0002-0763-3578
Carlos RochaMedical School, Group of Phytocomplexes and Cell Signaling, Anhembi Morumbi University, São José dos Campos 04039-002, Brazil.ORCID 0000-0001-8634-2850
Maurício Frota CamachoFunctional Proteomics Laboratory, Institute of Science and Technology, Federal University of São Paulo, São José dos Campos 12231-280, Brazil.ORCID 0000-0003-3894-2637
Uilla BarcickFunctional Proteomics Laboratory, Institute of Science and Technology, Federal University of São Paulo, São José dos Campos 12231-280, Brazil.ORCID 0000-0002-2029-8903
Andre ZelanisFunctional Proteomics Laboratory, Institute of Science and Technology, Federal University of São Paulo, São José dos Campos 12231-280, Brazil.ORCID 0000-0003-3066-6527
Flavio AimbireDepartment of Medicine, Postgraduate Program in Translational Medicine, Federal University of São Paulo (UNIFESP), Rua Pedro De Toledo 720-2 Andar, Vila Clementino, São Paulo 04039-002, Brazil.ORCID 0000-0002-4290-541X

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/03402-9
6 · The paper itself

Abstract

backgroundCytokine storm and oxidative stress are present in chronic obstructive pulmonary disease (COPD). Individuals with COPD present high levels of NF-κB-associated cytokines and pro-oxidant agents as well as low levels of Nrf2-associated antioxidants. This condition creates a steroid-resistant inflammatory microenvironment.

objectiveThus, we investigated the Lr effect on lung inflammation and oxidative stress in mice and macrophages exposed to cigarette smoke extract (CSE) and unresponsive to steroids.

methodsMice and macrophages received dexamethasone or GLPG-094 (a GPR43 inhibitor), and only the macrophages received butyrate (but), all treatments being given before CSE. Lung inflammation was evaluated from the leukocyte population, airway remodeling, cytokines, and NF-κB. Oxidative stress disturbance was measured from ROS, 8-isoprostane, NADPH oxidase, TBARS, SOD, catalase, HO-1, and Nrf2.

resultsLr attenuated cellularity, mucus, collagen, cytokines, ROS, 8-isoprostane, NADPH oxidase, and TBARS. Otherwise, SOD, catalase, HO-1, and Nrf2 were upregulated in Lr-treated COPD mice. Anti-cytokine and antioxidant effects of butyrate also occurred in CSE-exposed macrophages. GLPG-094 rendered Lr and butyrate less effective.

conclusionsLr attenuates lung inflammation and oxidative stress in COPD mice, suggesting the presence of a GPR43 receptor-dependent mechanism also found in macrophages.

Indexed as

Lacticaseibacillus rhamnosusMacrophagesOxidative StressPulmonary Disease, Chronic ObstructiveReceptors, G-Protein-CoupledAnimalsButyratesCytokinesDexamethasoneDisease Models, AnimalHumansInflammation MediatorsLungMaleMiceMice, Inbred C57BLButyratesCytokinesDexamethasoneFfar2 protein, mouseInflammation MediatorsReceptors, G-Protein-CoupledSmokeCOPDGPR43 receptorlung inflammationmacrophagesoxidative stressprobioticsteroid resistance

Identifiers

PMID38794746
PMCPMC11124176

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.