Evidence map›Paper›PMID 38795191›Full record

ArticleArchives of dermatological research2024

α5-nAChR/ADAM10 signaling mediates nicotine-related cutaneous melanoma progression via STAT3 activation.

Xiangying Li, Xianguang Meng, Huiping Fan, Yan Wang, Yanfei Jia, Jing Jiao, Xiaoli Ma

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of dermatological research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Smoking-Induced STC2Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiangying Li *Department of Dermatology, Central Hospital Affiliated to Shandong First Medical University, 105 Jiefang Street, Jinan, 250013, China.
Xianguang Meng *Department of Dermatology, Central Hospital Affiliated to Shandong First Medical University, 105 Jiefang Street, Jinan, 250013, China.
Huiping FanDepartment of Dermatology, Affiliated Hospital of Weifang Medical University, Weifang, China.
Yan WangDepartment of Dermatology, Jinan Central Hospital, Shandong University, Jinan, China.
Yanfei JiaResearch Center of Basic Medicine, Central Hospital Affiliated to Shandong First Medical University, 105 Jiefang Street, Jinan, 250013, China.
Jing JiaoDepartment of Dermatology, Central Hospital Affiliated to Shandong First Medical University, 105 Jiefang Street, Jinan, 250013, China. jj3286@zxyy.cn.
Xiaoli MaDepartment of Dermatology, Central Hospital Affiliated to Shandong First Medical University, 105 Jiefang Street, Jinan, 250013, China. Maxiaoli_jn@sdu.edu.cn.

Funding

National Natural Science Foundation of China 32170496Natural Science Foundation of Shandong Province ZR2022QC156
6 · The paper itself

Abstract

Skin cutaneous melanoma (SKCM) is the skin malignancy with the highest mortality rate, and its morbidity rate is on the rise worldwide. Smoking is an independent marker of poor prognosis in melanoma. The α5-nicotinic acetylcholine receptor (α5-nAChR), one of the receptors for nicotine, is involved in the proliferation, migration and invasion of SKCM cells. Nicotine has been reported to promote the expression of a disintegrin and metalloproteinase 10 (ADAM10), which is the key gene involved in melanoma progression. Here, we explored the link between α5-nAChR and ADAM10 in nicotine-associated cutaneous melanoma. α5-nAChR expression was correlated with ADAM10 expression and lower survival in SKCM. α5-nAChR mediated nicotine-induced ADAM10 expression via STAT3. The α5-nAChR/ADAM10 signaling axis was involved in the stemness and migration of SKCM cells. Furthermore, α5-nAChR expression was associated with ADAM10 expression, EMT marker expression and stemness marker expression in nicotine-related mice homograft tissues. These results suggest the role of the α5-nAChR/ADAM10 signaling pathway in nicotine-induced melanoma progression.

Indexed as

ADAM10 ProteinAmyloid Precursor Protein SecretasesCell MovementDisease ProgressionMelanomaMembrane ProteinsNicotineReceptors, NicotinicSignal TransductionSkin NeoplasmsSTAT3 Transcription FactorAnimalsCell Line, TumorCell ProliferationCutaneous Malignant MelanomaFemaleADAM10 ProteinADAM10 protein, humanAmyloid Precursor Protein SecretasesMembrane ProteinsNicotinenicotinic receptor alpha5 subunit, humanReceptors, NicotinicSTAT3 protein, humanSTAT3 Transcription FactorADAM10Cutaneous melanomaJAK2/STAT3Nicotineα5-nAChR

Identifiers

PMID38795191

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.