Evidence map›Paper›PMID 38797239›Full record

ArticleThe Journal of allergy and clinical immunology2024

Investigation of lactotransferrin messenger RNA expression levels as an anti-type 2 asthma biomarker.

Nicholas C Li, Natalie Iannuzo, Stephanie A Christenson, Paul R Langlais, Monica Kraft, Julie G Ledford, Xingnan Li

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Genome-wide Association Study IdentifiesAllergy, asthma & immunology research · 2026
    Article
  3. Article
  4. Validation ofJournal of thoracic disease · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Nicholas C LiUniversity of Arizona Internship, Basis Tucson North, Tucson, Ariz.
Natalie IannuzoDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, Ariz.
Stephanie A ChristensonDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep and Allergy, University of California, San Francisco, Calif.
Paul R LanglaisDepartment of Medicine, Division of Endocrinology, University of Arizona, Tucson, Ariz.
Monica KraftSamuel Bronfman Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Julie G LedfordDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, Ariz.
Xingnan LiSamuel Bronfman Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Medicine, Division of Genetics, Genomics and Precision Medicine, University of Arizona, Tucson, Ariz. Electronic address: lixingnan1@yahoo.com.

Funding

SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI George S Watts · 1994 to 2026
$36.7M
Defining mechanisms of CC16 on epithelial-driven host responses to pathogensR01HL142769 · NHLBI · UNIVERSITY OF ARIZONA · PI Julie Gunnells Ledford · 2019 to 2026
$4.2M
Fungal Asthma and Lung Innate ImmunityR01AI149754 · NIAID · UNIVERSITY OF ARIZONA · PI CHEN, YIN · 2020 to 2024
$2.6M
NHLBI NIH HHS R01 HL142769NIAID NIH HHS R01 AI149754NIEHS NIH HHS P30 ES006694
6 · The paper itself

Abstract

backgroundLactotransferrin (LTF) has an immunomodulatory function, and its expression levels are associated with asthma susceptibility.

objectivesWe sought to investigate LTF messenger RNA (mRNA) expression levels in human bronchial epithelial cells (BECs) as an anti-type 2 (T2) asthma biomarker.

methodsAssociation analyses between LTF mRNA expression levels in BECs and asthma-related phenotypes were performed in the Severe Asthma Research Program (SARP) cross-sectional (n = 155) and longitudinal (n = 156) cohorts using a generalized linear model. Correlation analyses of mRNA expression levels between LTF and all other genes were performed by Spearman correlation.

resultsLow LTF mRNA expression levels were associated with asthma susceptibility and severity (P < .025), retrospective and prospective asthma exacerbations, and low lung function (P < 8.3 × 10

conclusionsLow LTF mRNA expression levels in BECs are associated with asthma susceptibility, severity, and exacerbations through upregulation of airway T2 inflammation. LTF is a potential anti-T2 biomarker, and its expression levels may help determine the balance of eosinophilic and neutrophilic asthma.

Indexed as

AsthmaBiomarkersLactoferrinRNA, MessengerAdultBronchiCross-Sectional StudiesEpithelial CellsFemaleHumansMaleMiddle AgedTh2 CellsBiomarkersLactoferrinLTF protein, humanRNA, MessengerAnti-T2 biomarkerasthma exacerbationsasthma susceptibilitybronchial epithelial cellseosinophilslactotransferrinmRNA expressionneutrophilssevere asthmaT2 inflammation

Identifiers

PMID38797239
PMCPMC11380595

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.