Evidence map›Paper›PMID 38800487›Full record

ArticleFrontiers in endocrinology2024

Association between maternal and fetal inflammatory biomarkers and offspring weight and BMI during the first year of life in pregnancies with GDM: MySweetheart study.

Maria-Christina Antoniou, Dan Yedu Quansah, Leah Gilbert, Amar Arhab, Sybille Schenk, Alain Lacroix, Bobby Stuijfzand, Antje Horsch, Jardena Jacqueline Puder

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Observational
  3. Article
  4. Early Postpartum IL-10 and IL-37 Concentrations in Women with Gestational Diabetes Mellitus.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maria-Christina Antoniou *Unit of Pediatric Endocrinology and Diabetology, Pediatric Service, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland.
Dan Yedu Quansah *Obstetric Service, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland.
Leah GilbertObstetric Service, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland.
Amar ArhabObstetric Service, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland.
Sybille SchenkObstetric Service, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland.
Alain LacroixObstetric Service, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland.
Bobby StuijfzandObstetric Service, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland.
Antje HorschInstitute of Higher Education and Research in Healthcare (IUFRS), University of Lausanne, Lausanne, Switzerland.
Jardena Jacqueline PuderObstetric Service, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Gestational Diabetes Mellitus (GDM) is frequently associated with chronic, low-grade inflammation. Whether this environment affects offspring anthropometry during early childhood remains to be elucidated. The aim of this study was to investigate the associations between maternal and fetal (cord blood-umbilical artery) inflammatory biomarkers and offspring weight and BMI up to 1 year in pregnancies with GDM. Methods: In this prospective secondary analysis of the MySweetheart study, we included 193 women with GDM and their offspring. Maternal and fetal (N=39) predictors included serum levels of inflammatory biomarkers including CRP, IL-6, and TNF-α at 24-32 weeks of gestational age (GA) and in the cord blood. Offspring outcomes were small and large for gestational age (SGA, LGA), sex- and age-adjusted weight, and BMI at birth and at 1 year. Univariate and multivariate regression models were performed. Associations were adjusted for maternal pre-pregnancy BMI, age, and ethnicity. Results: Mean maternal age was 33.6 ± 4.8 years, and pre-pregnancy BMI 25.9 ± 5.6 kg/m Conclusions: In women with GDM, maternal and fetal inflammatory biomarkers distinctively influenced offspring anthropometry during the first year of life, independent of maternal age, prepregnancy BMI and ethnicity. These results suggest that low-grade inflammation during pregnancy may affect the developing offspring by leading to a decrease in weight and BMI and may have implications for future personalized follow-up of women with GDM and their offspring.

Indexed as

BiomarkersBirth WeightBody Mass IndexDiabetes, GestationalInflammationAdultBody WeightC-Reactive ProteinFemaleFetal BloodGestational AgeHumansInfantInfant, NewbornMalePregnancyBiomarkersC-Reactive Proteincord blood CRPgestational diabetesmaternal pro-inflammatory cytokinesoffspring anthropometryperinatal inflammation

Identifiers

PMID38800487
PMCPMC11116579

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.