Evidence map›Paper›PMID 38800655›Full record

ArticleArXiv2024

Fully Automated OCT-based Tissue Screening System.

Shaohua Pi, Razieh Ganjee, Lingyun Wang, Riley K Arbuckle, Chengcheng Zhao, Jose A Sahel, Bingjie Wang, Yuanyuan Chen

Abstract readPreprint
PubMed Full text at PMC
In one paragraph

Article in ArXiv, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Shaohua PiDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Razieh GanjeeDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Lingyun WangDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Riley K ArbuckleDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Chengcheng ZhaoDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Jose A SahelDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Bingjie WangDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Yuanyuan ChenDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Funding

Virus Production and Manipulation of Protein/Gene Expression ModuleP30EY008098 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yuanyuan Chen · 1989 to 2026
$17.8M
Pharmacological studies of rhodopsin metabolismR01EY030991 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yuanyuan Chen · 2020 to 2026
$2.3M
NEI NIH HHS P30 EY008098NEI NIH HHS R01 EY030991
6 · The paper itself

Abstract

This study introduces a groundbreaking optical coherence tomography (OCT) imaging system dedicated for high-throughput screening applications using ex vivo tissue culture. Leveraging OCT's non-invasive, high-resolution capabilities, the system is equipped with a custom-designed motorized platform and tissue detection ability for automated, successive imaging across samples. Transformer-based deep learning segmentation algorithms further ensure robust, consistent, and efficient readouts meeting the standards for screening assays. Validated using retinal explant cultures from a mouse model of retinal degeneration, the system provides robust, rapid, reliable, unbiased, and comprehensive readouts of tissue response to treatments. This fully automated OCT-based system marks a significant advancement in tissue screening, promising to transform drug discovery, as well as other relevant research fields.

Identifiers

PMID38800655
PMCPMC11118679

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.