ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2024
Identification of symptom clusters and sentinel symptoms during the first cycle of chemotherapy in patients with lung cancer.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Article
- Longitudinal identification of sentinel symptoms across frailty dimensions in lung cancer patients undergoing radiotherapy.Discover oncology · 2026Article
- Early chemotherapy symptom clusters predict quality of life and treatment adherence in lung cancer patients.Discover oncology · 2026Article
- Joint nausea and fatigue profiles during chemotherapy identify patients with a higher symptom burden.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- The Symptom Clusters and Core Symptoms in Patients with Lung Cancer After Surgery: A Longitudinal Network Analysis.Patient preference and adherence · 2026Article
- Metabolic dysregulation associated with core symptom cluster in lung cancer patients undergoing chemotherapy.British journal of cancer · 2026Article
- Exploring core and sentinel symptoms in elderly patients with type 2 diabetes through network analysis and the Apriori algorithm.Frontiers in medicine · 2026Article
- Investigating the symptoms and sentinel symptoms of patients with lymphoma during chemotherapy: a cross-sectional survey.BMJ open · 2025Article
- Trajectories of fatigue-pain-sleep disturbance symptom cluster in patients with lung cancer undergoing chemotherapy and its predictive factors: Latent class growth model.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Experiences of the fatigue-pain-sleep disturbance symptom cluster among patients with lung cancer: A descriptive qualitative study.Asia-Pacific journal of oncology nursing · 2025Article
- Symptom clusters and sentinel symptoms during post-transplant recovery in recipients of allogeneic hematopoietic stem cell transplantation: A cross-sectional study.Asia-Pacific journal of oncology nursing · 2025Article
- Identification of symptom clusters and sentinel symptoms in preoperative patients with oral and maxillofacial cancers: A cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Construction of the central symptom cluster management program for patients with lung cancer undergoing chemotherapy: a Delphi study.BMC nursing · 2025Article
- Cross-Lag Analysis of Prognostic Nutritional Index and Psychosomatic Symptom Clusters in Patients with Lung Cancer: A Longitudinal Study.Cancer management and research · 2025Article
- Shengxian decoction alleviates cyclophosphamide-induced immunosuppression via improving B cell-mediated immune responses.Frontiers in pharmacology · 2025Article
- Identification of Symptom Clusters and Sentinel Symptoms During Radiotherapy in Lung Cancer Patients: A Longitudinal Study.Cancer management and research · 2025Article
- Symptom clusters and impact on quality of life in lung cancer patients undergoing chemotherapy.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Trajectories of depression and predictors in lung cancer patients undergoing chemotherapy: growth mixture model.BMC psychiatry · 2024Article
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6 authors.
Funding
Abstract
purposeTo identify symptom clusters (SCs) in patients with lung cancer who are undergoing initial chemotherapy and to identify the sentinel symptoms of each SC.
methodsA convenience sampling method was used to recruit patients with lung cancer who were undergoing their initial chemotherapy treatment. Patient information was collected using the General Demographic Questionnaire, MD Anderson Symptom Inventory (including the lung cancer module) and a schedule documenting the initial occurrence of symptoms. The Walktrap algorithm was employed to identify SCs, while sentinel symptoms within each SC were identified using the Apriori algorithm in conjunction with the initial occurrence time of symptoms.
resultsA total of 169 patients with lung cancer participated in this study, and four SCs were identified: the psychological SC (difficulty remembering, sadness, dry mouth, numbness or tingling, and distress), somatic SC (pain, fatigue, sleep disturbance, and drowsiness), respiratory SC (coughing, expectoration, chest tightness, and shortness of breath), and digestive SC (nausea, poor appetite, constipation, vomiting, and weight loss). Sadness, fatigue, and coughing were identified as sentinel symptoms of the psychological, somatic, and respiratory SCs, respectively. However, no sentinel symptom was identified for the digestive SC.
conclusionPatients with lung cancer who are undergoing chemotherapy encounter a spectrum of symptoms, often presenting as SCs. The sentinel symptom of each SC emerges earlier than the other symptoms and is characterized by its sensitivity, significance, and driving force. It serves as a vital indicator of the SC and assumes a sentry role. Targeting sentinel symptoms might be a promising strategy for determining the optimal timing of interventions and for mitigating or decelerating the progression of the other symptoms within the SC.
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