Evidence map›Paper›PMID 38804618›Full record

ArticleACS chemical neuroscience2024

Protein Painting Mass Spectrometry in the Discovery of Interaction Sites within the Acetylcholine Binding Protein.

Alexandru Graur, Amanda Haymond, Kyung Hyeon Lee, Franco Viscarra, Paul Russo, Alessandra Luchini, Mikell Paige, Isabel Bermudez-Diaz, Nadine Kabbani

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. State-of-the-Art and Future Directions in Structural Proteomics.Molecular & cellular proteomics : MCP · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alexandru GraurSchool of Systems Biology, George Mason University, Fairfax, Virginia 22030, United States.
Amanda HaymondCenter for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia 20110, United States.
Kyung Hyeon LeeDepartment of Chemistry and Biochemistry, George Mason University, Fairfax, Virginia 20110, United States.ORCID 0000-0002-6794-5223
Franco ViscarraDepartment of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Headington, Oxford OX3 0BP, United Kingdom.
Paul RussoCenter for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia 20110, United States.
Alessandra LuchiniCenter for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia 20110, United States.
Mikell PaigeDepartment of Chemistry and Biochemistry, George Mason University, Fairfax, Virginia 20110, United States.
Isabel Bermudez-DiazDepartment of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Headington, Oxford OX3 0BP, United Kingdom.
Nadine KabbaniSchool of Systems Biology, George Mason University, Fairfax, Virginia 22030, United States.ORCID 0000-0001-5515-3782

Funding

New Hybrid Molecular Modalities Comprised of DNA-Origami and Interfering Peptides as Inhibitors of Protein-Protein InteractionsR21CA251015 · NCI · GEORGE MASON UNIVERSITY · PI STILL, AMANDA NICOLE HAYMOND · 2021 to 2023
$522k
NCI NIH HHS R21 CA251015
6 · The paper itself

Abstract

Nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion channel receptors that contribute to cognition, memory, and motor control in many organisms. The pharmacological targeting of these receptors, using small molecules or peptides, presents an important strategy for the development of drugs that can treat important human diseases, including neurodegenerative disorders. The

Indexed as

AplysiaMass SpectrometryReceptors, NicotinicAcetylcholineAmyloid beta-PeptidesAnimalsBinding SitesBungarotoxinsCarrier ProteinsModels, MolecularProtein BindingAcetylcholineAmyloid beta-PeptidesBungarotoxinsCarrier ProteinsReceptors, Nicotinicamyloidbungarotoxinligand bindingnicotinic receptorprotein interactions

Identifiers

PMID38804618
PMCPMC11157483

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.