Evidence map›Paper›PMID 38805089›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2024

Individual cerebellar metabolic connectome in patients with MTLE and NTLE associated with surgical prognosis.

Yongxiang Tang, Haoyue Zhu, Ling Xiao, Rong Li, Honghao Han, Weiting Tang, Ding Liu, Chunyao Zhou, Dingyang Liu, Zhiquan Yang and 6 more

Abstract read
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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Frontiers in medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yongxiang Tang *Department of Nuclear Medicine, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.
Haoyue Zhu *Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Rd, Changsha, 410008, PR China.
Ling XiaoDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.
Rong LiThe Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Honghao HanThe Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Weiting TangDepartment of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Rd, Changsha, 410008, PR China.
Ding LiuDepartment of Neurology, The Third Xiangya Hospital, Central South University, Changsha, China.
Chunyao ZhouDepartment of Neurosurgery, Xiangya Hospital, Central Southern University, Changsha, China.
Dingyang LiuDepartment of Neurosurgery, Xiangya Hospital, Central Southern University, Changsha, China.
Zhiquan YangDepartment of Neurosurgery, Xiangya Hospital, Central Southern University, Changsha, China.
Luo ZhouDepartment of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Rd, Changsha, 410008, PR China.
Bo XiaoDepartment of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Rd, Changsha, 410008, PR China.
Axel RomingerDepartment of Nuclear Medicine, Inselspital, University Hospital Bern, Bern, Switzerland.
Kuangyu ShiDepartment of Nuclear Medicine, Inselspital, University Hospital Bern, Bern, Switzerland.
Shuo HuDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China. hushuo2018@163.com.
Li FengDepartment of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Rd, Changsha, 410008, PR China. fenglihx@163.com.ORCID 0000-0001-7658-1399

Funding

China Postdoctoral Science Foundation 2022M723561Clinical Research Foundation of the National Clinical Research Center for Geriatric Diseases(XIANGYA) 2020LNJJ01Clinical Research Foundation of the National Clinical Research Center for Geriatric Diseases(XIANGYA) 2023LNJJ16Innovative Construction Foundation of Hunan Province 2021SK4001Key Technologies Research and Development Program 2022YFC2503804Ministry of Industry and Information Technology of the People's Republic of China CEIEC-2022-ZM02-0219National Natural Science Foundation of China 81801740National Natural Science Foundation of China 82071461National Natural Science Foundation of China 82271503National Natural Science Foundation of China 82272045National Natural Science Foundation of China 82301649National Natural Science Foundation of China 91859207Natural Science Foundation of Hunan Province 2020JJ5922Natural Science Foundation of Hunan Province 2021JJ31060Natural Science Foundation of Hunan Province 2023JJ30939Science and Technology Innovation Program of Hunan Province 2021RC4056Science Fund for Distinguished Young Scholars of Hunan Province 2024JJ2094The National Key Clinical Specialty Major Scientific Research Project of Hunan Province Z2023004
6 · The paper itself

Abstract

purposeThis study aimed to comprehensively explore the different metabolic connectivity topological changes in MTLE and NTLE, as well as their association with surgical outcomes.

methodsThis study enrolled a cohort of patients with intractable MTLE and NTLE. Each individual's metabolic connectome, as determined by Kullback-Leibler divergence similarity estimation for the [

resultsBoth MTLE and NTLE patients exhibited substantial alterations in the connectivity of the metabolic network at the edge and nodal levels (p < 0.01, FDR corrected). The key disparity between MTLE and NTLE was observed in the cerebellum. In MTLE, there was a predominance of increased connectivity strength in the cerebellum. Whereas, a decrease in cerebellar connectivity was identified in NTLE. It was found that in MTLE, higher edge connectivity and weighted connectivity strength in the contralateral cerebellar hemisphere correlated with improved surgical outcomes. Conversely, in NTLE, a higher edge metabolic connectivity strength in the ipsilateral cerebellar hemisphere suggested a worse surgical prognosis.

conclusionThe cerebellum exhibits distinct topological characteristics in the metabolic networks between MTLE and NTLE. The hyper- or hypo-metabolic connectivity in the cerebellum may be a prognostic biomarker of surgical prognosis, which might aid in therapeutic decision-making for TLE individuals.

Indexed as

CerebellumConnectomeEpilepsy, Temporal LobeAdolescentAdultCohort StudiesFemaleFluorodeoxyglucose F18HumansMalePositron-Emission TomographyRetrospective StudiesYoung AdultFluorodeoxyglucose F18CerebellumMetabolic connectomeMTLENTLESurgical prognosis

Identifiers

PMID38805089

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.