Evidence map›Paper›PMID 38809710›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

NAD activates olfactory receptor 1386 to regulate type I interferon responses in

Yu-Chih Peng, Jian Wu, Xiao He, Jin Dai, Lu Xia, Paola Valenzuela-Leon, Keyla C Tumas, Brajesh K Singh, Fangzheng Xu, Sundar Ganesan and 6 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Antagonists Enhance Cell-Surface Expression of Mammalian Odorant Receptors.International journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yu-Chih Peng *Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, NIH, Rockville, MD 20852.
Jian Wu *Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, NIH, Rockville, MD 20852.ORCID 0000-0001-5784-6160
Xiao He *Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, NIH, Rockville, MD 20852.
Jin DaiRNA Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Lu XiaHunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Disease of Ministry of Education, School of Life Sciences, Central South University, Changsha, Hunan 410083, People's Republic of China.ORCID 0000-0003-2450-1320
Paola Valenzuela-LeonLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, NIH, Rockville, MD 20852.ORCID 0000-0002-5740-5178
Keyla C TumasLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, NIH, Rockville, MD 20852.
Brajesh K SinghLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, NIH, Rockville, MD 20852.
Fangzheng XuLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, NIH, Rockville, MD 20852.
Sundar GanesanBiological Imaging Section, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Shirin MunirRNA Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.ORCID 0000-0002-8493-0728
Eric CalvoLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, NIH, Rockville, MD 20852.ORCID 0000-0001-7880-2730
Ruili HuangNational Center for Advancing Translational Sciences, NIH, Bethesda, MD 20892.
Chengyu LiuTransgenic Core Facility, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892.ORCID 0000-0002-5136-9225
Carole A LongLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, NIH, Rockville, MD 20852.
Xin-Zhuan SuLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, NIH, Rockville, MD 20852.ORCID 0000-0003-3246-3248

Funding

Infectious Diseases Research Technologies Core - BethesdaZICAI001051 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CHERRY, JAMES · 2009 to 2025
$226.1M
Transgenic CoreZICHL005907 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LIU, CHENGYU · 2010 to 2025
$25.8M
Laboratory And Pre-clinical Studies Of Parainfluenza VirusesZIAAI000327 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BUCHHOLZ, URSULA · 2009 to 2025
$23.7M
Malaria Parasite Sexual Development, Drug Resistance, and EvolutionZIAAI000892 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SU, XINZHUAN · 2009 to 2025
$23.3M
Host Immune Responses to Antigens of Malaria ParasitesZIAAI001020 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LONG, CAROLE · 2009 to 2025
$13.6M
Arthropod saliva in vector-borne disease transmission: Functional analysis of novel domains in salivary secretionsZIAAI001246 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CALVO, ERIC · 2019 to 2025
$10.0M
Toxicology in the 21st Century Program (Tox21) - Computational ToxicologyZIATR000040 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI HUANG, RUILI · 2016 to 2025
$3.5M
HHS | NIH | National Center for Advancing Translational Sciences (NCATS) intramuralHHS | NIH | NIAID | Division of Intramural Research (DIR, NIAID) IntramuralNational Science Foundation of Human Province 2022RC1069 and 2021SK1010
6 · The paper itself

Abstract

Olfactory receptors (Olfr) are G protein-coupled receptors that are normally expressed on olfactory sensory neurons to detect volatile chemicals or odorants. Interestingly, many Olfrs are also expressed in diverse tissues and function in cell-cell recognition, migration, and proliferation as well as immune responses and disease processes. Here, we showed that many Olfr genes were expressed in the mouse spleen, linked to

Indexed as

Interferon Type IMalariaPlasmodium yoeliiReceptors, OdorantAnimalsHEK293 CellsHumansMiceMice, Inbred C57BLMice, KnockoutSignal TransductionInterferon Type IReceptors, OdorantG protein–coupled receptorimmune responsesmousePlasmodiumsignaling

Identifiers

PMID38809710
PMCPMC11161801

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.