ArticleNeurobiology of aging2024
Testing the structural disconnection hypothesis: Myelin content correlates with memory in healthy aging.
Article in Neurobiology of aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- A Comprehensive Characterization of the Phospholipid and Cholesterol Composition of the Uncinate Fasciculus in the Human Brain: Evidence of Age-Related Alterations.Journal of neurochemistry · 2026Article
- Molecular and Clinical Considerations for Anesthesia in the Aging Brain.International journal of molecular sciences · 2025Review
- Myelin dysfunction in aging and brain disorders: mechanisms and therapeutic opportunities.Molecular neurodegeneration · 2025Review
- Synergistic effects of plasma S100B and MRI measures of cerebrovascular disease on cognition in older adults.GeroScience · 2025Article
- Electroacupuncture treatment can improve cognitive impairment in spontaneously hypertensive rats: a preliminary DTI study.Frontiers in neuroscience · 2025Article
- The cognitive neuroscience and neurocognitive rehabilitation of dance.BMC neuroscience · 2024Review
- Harnessing myelin water fraction as an imaging biomarker of human cerebral aging, neurodegenerative diseases, and risk factors influencing myelination: A review.Journal of neurochemistry · 2024Review
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Authors and funding
11 authors.
Funding
Abstract
introductionThe "structural disconnection" hypothesis of cognitive aging suggests that deterioration of white matter (WM), especially myelin, results in cognitive decline, yet in vivo evidence is inconclusive.
methodsWe examined age differences in WM microstructure using Myelin Water Imaging and Diffusion Tensor Imaging in 141 healthy participants (age 20-79). We used the Virginia Cognitive Aging Project and the NIH Toolbox® to generate composites for memory, processing speed, and executive function.
resultsVoxel-wise analyses showed that lower myelin water fraction (MWF), predominantly in prefrontal WM, genu of the corpus callosum, and posterior limb of the internal capsule was associated with reduced memory performance after controlling for age, sex, and education. In structural equation modeling, MWF in the prefrontal white matter and genu of the corpus callosum significantly mediated the effect of age on memory, whereas fractional anisotropy (FA) did not. DISCUSSION: Our findings support the disconnection hypothesis, showing that myelin decline contributes to age-related memory loss and opens avenues for interventions targeting myelin health.
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