Evidence map›Paper›PMID 38810702›Full record

ReviewAdvanced drug delivery reviews2024

Multiscale engineering of brain organoids for disease modeling.

Cong Xu, Alia Alameri, Wei Leong, Emily Johnson, Zaozao Chen, Bin Xu, Kam W Leong

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced drug delivery reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cong XuDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Alia AlameriDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Wei LeongDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Emily JohnsonDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Zaozao ChenDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Bin XuDepartment of Psychiatry, Columbia University, New York, NY 10032, USA. Electronic address: bx2105@cumc.columbia.edu.
Kam W LeongDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA. Electronic address: kamleong1@gmail.com.

Funding

Integrated Microphysiological System of Cerebral Organoid and Blood Vessel for Disease Modeling and Neuropsychiatric Drug screeningUH3TR002151 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEONG, KAM W · 2020 to 2022
$3.6M
Integrated Microphysiological System of Cerebral Organoid and Blood Vessel for Disease Modeling and Neuropsychiatric Drug screeningUG3TR002151 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEONG, KAM W · 2018 to 2019
$2.6M
Focused Ultrasound-mediated Delivery of Gene-editing Elements to the Brain for Neurodegenerative DisordersUG3NS115598 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEONG, KAM W · 2019 to 2021
$2.3M
Focused Ultrasound-mediated Delivery of Gene-editing Elements to the Brain for Neurodegenerative DisordersUH3NS115598 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEONG, KAM W · 2022 to 2022
$1.6M
NCATS NIH HHS UG3 TR002151NCATS NIH HHS UH3 TR002151NINDS NIH HHS UG3 NS115598NINDS NIH HHS UH3 NS115598
6 · The paper itself

Abstract

Brain organoids hold great potential for modeling human brain development and pathogenesis. They recapitulate certain aspects of the transcriptional trajectory, cellular diversity, tissue architecture and functions of the developing brain. In this review, we explore the engineering strategies to control the molecular-, cellular- and tissue-level inputs to achieve high-fidelity brain organoids. We review the application of brain organoids in neural disorder modeling and emerging bioengineering methods to improve data collection and feature extraction at multiscale. The integration of multiscale engineering strategies and analytical methods has significant potential to advance insight into neurological disorders and accelerate drug development.

Indexed as

BrainOrganoidsAnimalsBioengineeringHumansModels, BiologicalNervous System DiseasesTissue EngineeringBrain developmentBrain organoidDisease modelingPluripotent stem cellTissue engineering

Identifiers

PMID38810702
PMCPMC11265575

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.