Evidence map›Paper›PMID 38810948›Full record

ArticleNeurobiology of disease2024

Evidence of mutant huntingtin and tau-related pathology within neuronal grafts in Huntington's disease cases.

Shireen Salem, Mitchell D Kilgore, Mehwish Anwer, Alexander Maxan, Dan Child, Thomas D Bird, C Dirk Keene, Francesca Cicchetti, Caitlin Latimer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shireen SalemCentre de Recherche du CHU de Québec, Axe Neurosciences, T2-07, 2705, Boulevard Laurier, Québec, QC G1V 4G2, Canada; Departement de Médecine Moléculaire, Université Laval, Québec, QC, Canada.
Mitchell D KilgoreDepartment of Laboratory Medicine and Pathology, Neuropathology Division, University of Washington, Seattle, WA, USA.
Mehwish AnwerCentre de Recherche du CHU de Québec, Axe Neurosciences, T2-07, 2705, Boulevard Laurier, Québec, QC G1V 4G2, Canada; Departement de Psychiatrie et Neurosciences, Université Laval, Québec, QC, Canada.
Alexander MaxanCentre de Recherche du CHU de Québec, Axe Neurosciences, T2-07, 2705, Boulevard Laurier, Québec, QC G1V 4G2, Canada; Departement de Psychiatrie et Neurosciences, Université Laval, Québec, QC, Canada.
Dan ChildDepartment of Laboratory Medicine and Pathology, Neuropathology Division, University of Washington, Seattle, WA, USA.
Thomas D BirdDepartment of Neurology, University of Washington, Seattle, WA, USA; Geriatric Research, Education, and Clinical Center (GRECC), VA Puget Sound Health Care System, Seattle, WA, USA.
C Dirk KeeneDepartment of Laboratory Medicine and Pathology, Neuropathology Division, University of Washington, Seattle, WA, USA.
Francesca CicchettiCentre de Recherche du CHU de Québec, Axe Neurosciences, T2-07, 2705, Boulevard Laurier, Québec, QC G1V 4G2, Canada; Departement de Médecine Moléculaire, Université Laval, Québec, QC, Canada; Departement de Psychiatrie et Neurosciences, Université Laval, Québec, QC, Canada. Electronic address: francesca.cicchetti@crchudequebec.ulaval.ca.
Caitlin LatimerDepartment of Laboratory Medicine and Pathology, Neuropathology Division, University of Washington, Seattle, WA, USA. Electronic address: caitlinl@uw.edu.

Funding

University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Jeffrey J Iliff · 2020 to 2026
$29.0M
Molecular Mechanisms of Synergistic TDP-43 and Tau Proteotoxicity in Alzheimer's DiseaseK08AG065426 · NIA · UNIVERSITY OF WASHINGTON · PI LATIMER, CAITLIN SHANNON · 2020 to 2024
$705k
NIA NIH HHS K08 AG065426NIA NIH HHS P30 AG066509
6 · The paper itself

Abstract

A number of post-mortem studies conducted in transplanted Huntington's disease (HD) patients from various trials have reported the presence of pathological and misfolded proteins, in particular mutant huntingtin (mHtt) and phosphorylated tau neuropil threads, in the healthy grafted tissue. Here, we extended these observations with histological analysis of post-mortem tissue from three additional HD patients who had received similar striatal allografts from the fetal tissue transplantation trial conducted in Los Angeles in 1998. Immunohistochemical staining was performed using anti-mHtt antibodies, EM48 and MW7, as well as anti-hyperphosphorylated tau antibodies, AT8 and CP13. Immunofluorescence was used to assess the colocalization of EM48

Indexed as

Huntingtin ProteinHuntington DiseaseNeuronstau ProteinsAdultAgedBrain Tissue TransplantationFemaleFetal Tissue TransplantationHumansMaleMiddle AgedHTT protein, humanHuntingtin Proteintau ProteinsFetal neural transplantationHuntington’s diseaseMutant huntingtin proteintau

Identifiers

PMID38810948
PMCPMC12448652

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.