Evidence map›Paper›PMID 38811501›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2024

Sex differences in atrial fibrillation ablation outcomes in patients with heart failure.

Siddharth Agarwal, Kassem Farhat, Muhammad Salman Khan, Christopher V DeSimone, Abhishek Deshmukh, Muhammad Bilal Munir, Zain Ul Abideen Asad, Stavros Stavrakis

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Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Siddharth AgarwalDepartment of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.ORCID http://orcid.org/0000-0002-5581-5464
Kassem FarhatDepartment of Internal Medicine, Yale School of Medicine, Waterbury, CT, USA.
Muhammad Salman KhanDepartment of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Christopher V DeSimoneDepartment of Cardiology, Mayo Clinic, Rochester, MN, USA.
Abhishek DeshmukhDepartment of Cardiology, Mayo Clinic, Rochester, MN, USA.
Muhammad Bilal MunirDivision of Cardiovascular Medicine, University of California Davis, Sacramento, CA, USA.
Zain Ul Abideen AsadDepartment of Cardiology, University of Oklahoma Health Sciences Center, 800 Stanton L Young Blvd, Suite 5400, Oklahoma City, OK, 73104, USA.
Stavros StavrakisDepartment of Cardiology, University of Oklahoma Health Sciences Center, 800 Stanton L Young Blvd, Suite 5400, Oklahoma City, OK, 73104, USA. Stavros-stavrakis@ouhsc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is a lack of data on the impact of sex on the outcomes of patients with heart failure (HF) undergoing atrial fibrillation (AF) ablation. We aimed to analyze the association of sex with outcomes of atrial fibrillation ablation in patients with heart failure.

methodsThe National Readmissions Database (NRD) was analyzed from 2016 to 2019 to identify patients ≥ 18 years old with heart failure (HF) undergoing AF ablation. The outcomes of interest included peri-procedural complications, in-hospital mortality, resource utilization, and unplanned 1-year readmissions. The final cohort was divided into patients with HFrEF and HFpEF and outcomes were compared between males and females in both cohorts.

resultsA total of 23,277 patients with HF underwent AF ablation between 2016 and 2019, of which 14,480 had HFrEF and 8,797 had HFpEF. Among patients with HFrEF, 61.6% were males and 38.4% were females whereas, among patients with HFpEF, 35.4% were males and 64.6% were females. On a multivariable-adjusted analysis, in patients with HFrEF, there was no difference in the odds of in-hospital mortality, peri-procedural complications, or 1-year HF-related/AF-related/all-cause readmissions between males and females. In patients with HFpEF, females had a higher risk 1-year HF-related readmissions (adjusted hazards ratio: 1.46; 95% CI: 1.13-1.87; p = 0.01), without any difference in the 1-year AF-related/all-cause readmissions, in-hospital mortality, or peri-procedural complications.

conclusionOur results show that females with HFrEF undergoing AF ablation have similar outcomes whereas females with HFpEF have higher 1-year HF readmissions with no difference in the other outcomes, compared to males.

Indexed as

Atrial FibrillationCatheter AblationHeart FailureHospital MortalityPatient ReadmissionAgedDatabases, FactualFemaleHumansMaleMiddle AgedPostoperative ComplicationsRetrospective StudiesSex FactorsTreatment OutcomeUnited StatesAblationAtrial fibrillationHeart failureMortalityOutcomesSex differences

Identifiers

PMID38811501

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.