Evidence map›Paper›PMID 38811670›Full record

ArticleScientific reports2024

Detection of atherosclerotic plaques with HDL-like porphyrin nanoparticles using an intravascular dual-modality optical coherence tomography and fluorescence system.

Rouyan Chen, Lauren Sandeman, Victoria Nankivell, Joanne T M Tan, Mohammad Rashidi, Peter J Psaltis, Gang Zheng, Christina Bursill, Robert A McLaughlin, Jiawen Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rouyan ChenSchool of Electrical and Mechanical Engineering, Faculty of Sciences, Engineering and Technology, The University of Adelaide, Adelaide, SA, 5005, Australia. rouyan.chen@adelaide.edu.au.
Lauren SandemanVascular Research Centre, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, 5000, Australia.
Victoria NankivellVascular Research Centre, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, 5000, Australia.
Joanne T M TanVascular Research Centre, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, 5000, Australia.
Mohammad RashidiInstitute for Photonics and Advanced Sensing, The University of Adelaide, Adelaide, SA, 5005, Australia.
Peter J PsaltisVascular Research Centre, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, 5000, Australia.
Gang ZhengDepartment of Medical Biophysics, University of Toronto, Toronto, ON, M5G 1L7, Canada.
Christina BursillVascular Research Centre, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, 5000, Australia.
Robert A McLaughlinInstitute for Photonics and Advanced Sensing, The University of Adelaide, Adelaide, SA, 5005, Australia.
Jiawen LiSchool of Electrical and Mechanical Engineering, Faculty of Sciences, Engineering and Technology, The University of Adelaide, Adelaide, SA, 5005, Australia. jiawen.li01@adelaide.edu.au.

Funding

Hospital Research Foundation 2022-CP-IDMH-014-83100National Health and Medical Research Council 1178912National Health and Medical Research Council 1184571National Health and Medical Research Council 2008462National Health and Medical Research Council (NHMRC) 2001646National Heart Foundation of Australia 106656Wellcome Trust 105608
6 · The paper itself

Abstract

Atherosclerosis is the build-up of fatty plaques within blood vessel walls, which can occlude the vessels and cause strokes or heart attacks. It gives rise to both structural and biomolecular changes in the vessel walls. Current single-modality imaging techniques each measure one of these two aspects but fail to provide insight into the combined changes. To address this, our team has developed a dual-modality imaging system which combines optical coherence tomography (OCT) and fluorescence imaging that is optimized for a porphyrin lipid nanoparticle that emits fluorescence and targets atherosclerotic plaques. Atherosclerosis-prone apolipoprotein (Apo)e

Indexed as

NanoparticlesPlaque, AtheroscleroticPorphyrinsTomography, Optical CoherenceAnimalsAtherosclerosisDisease Models, AnimalLipoproteins, HDLMacrophagesMiceOptical ImagingLipoproteins, HDLPorphyrins

Identifiers

PMID38811670
PMCPMC11136962

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.