Evidence map›Paper›PMID 38813696›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2024

Single-Nucleus Transcriptomic Atlas of Human Pericoronary Epicardial Adipose Tissue in Normal and Pathological Conditions.

Xuanyu Liu, Meng Yuan, Danni Zhao, Qingyi Zeng, Wenke Li, Tianjiao Li, Qi Li, Yue Zhuo, Mingyao Luo, Pengfei Chen and 3 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Biomarkers of Cardiac Metabolic Flexibility in Health, HFrEF and HFpEF.International journal of molecular sciences · 2026
    Review
  6. Inflammation and Resolution in Obesity-Related Cardiovascular Disease.International journal of molecular sciences · 2026
    Review
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xuanyu LiuState Key Laboratory of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.L., M.Y., D.Z., Q.Z., W.L., T.L., Q.L., Y.Z., M.L., P.C., L.W., W.F., Z.Z.).ORCID 0000-0002-5935-2102
Meng YuanState Key Laboratory of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.L., M.Y., D.Z., Q.Z., W.L., T.L., Q.L., Y.Z., M.L., P.C., L.W., W.F., Z.Z.).ORCID 0009-0002-5504-6041
Danni ZhaoState Key Laboratory of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.L., M.Y., D.Z., Q.Z., W.L., T.L., Q.L., Y.Z., M.L., P.C., L.W., W.F., Z.Z.).ORCID 0009-0002-4902-8955
Qingyi ZengState Key Laboratory of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.L., M.Y., D.Z., Q.Z., W.L., T.L., Q.L., Y.Z., M.L., P.C., L.W., W.F., Z.Z.).ORCID 0000-0002-2607-306X
Wenke LiState Key Laboratory of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.L., M.Y., D.Z., Q.Z., W.L., T.L., Q.L., Y.Z., M.L., P.C., L.W., W.F., Z.Z.).ORCID 0000-0003-0984-9468
Tianjiao LiState Key Laboratory of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.L., M.Y., D.Z., Q.Z., W.L., T.L., Q.L., Y.Z., M.L., P.C., L.W., W.F., Z.Z.).ORCID 0000-0001-9422-3210
Qi LiState Key Laboratory of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.L., M.Y., D.Z., Q.Z., W.L., T.L., Q.L., Y.Z., M.L., P.C., L.W., W.F., Z.Z.).ORCID 0009-0005-1124-5956
Yue ZhuoState Key Laboratory of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.L., M.Y., D.Z., Q.Z., W.L., T.L., Q.L., Y.Z., M.L., P.C., L.W., W.F., Z.Z.).ORCID 0009-0002-1878-917X
Mingyao LuoState Key Laboratory of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.L., M.Y., D.Z., Q.Z., W.L., T.L., Q.L., Y.Z., M.L., P.C., L.W., W.F., Z.Z.).ORCID 0009-0008-1074-9740
Pengfei ChenState Key Laboratory of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.L., M.Y., D.Z., Q.Z., W.L., T.L., Q.L., Y.Z., M.L., P.C., L.W., W.F., Z.Z.).ORCID 0000-0002-0090-3475
Liqing WangState Key Laboratory of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.L., M.Y., D.Z., Q.Z., W.L., T.L., Q.L., Y.Z., M.L., P.C., L.W., W.F., Z.Z.).ORCID 0009-0002-4342-6880
Wei FengState Key Laboratory of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.L., M.Y., D.Z., Q.Z., W.L., T.L., Q.L., Y.Z., M.L., P.C., L.W., W.F., Z.Z.).ORCID 0009-0006-2609-1109
Zhou ZhouState Key Laboratory of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (X.L., M.Y., D.Z., Q.Z., W.L., T.L., Q.L., Y.Z., M.L., P.C., L.W., W.F., Z.Z.).ORCID 0000-0002-1060-0355

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPericoronary epicardial adipose tissue (EAT) is a unique visceral fat depot that surrounds the adventitia of the coronary arteries without any anatomic barrier. Clinical studies have demonstrated the association between EAT volume and increased risks for coronary artery disease (CAD). However, the cellular and molecular mechanisms underlying the association remain elusive.

methodsWe performed single-nucleus RNA sequencing on pericoronary EAT samples collected from 3 groups of subjects: patients undergoing coronary bypass surgery for severe CAD (n=8), patients with CAD with concomitant type 2 diabetes (n=8), and patients with valvular diseases but without concomitant CAD and type 2 diabetes as the control group (n=8). Comparative analyses were performed among groups, including cellular compositional analysis, cell type-resolved transcriptomic changes, gene coexpression network analysis, and intercellular communication analysis. Immunofluorescence staining was performed to confirm the presence of CAD-associated subclusters.

resultsUnsupervised clustering of 73 386 nuclei identified 15 clusters, encompassing all known cell types in the adipose tissue. Distinct subpopulations were identified within primary cell types, including adipocytes, adipose stem and progenitor cells, and macrophages.

conclusionsWe built a complete single-nucleus transcriptomic atlas of human pericoronary EAT in normal and diseased conditions of CAD. Our study lays the foundation for developing novel therapeutic strategies for treating CAD by targeting and modifying pericoronary EAT functions.

Indexed as

Adipose TissueCoronary Artery DiseasePericardiumTranscriptomeAdipocytesAgedCase-Control StudiesCoronary Artery BypassDiabetes Mellitus, Type 2Epicardial Adipose TissueFemaleGene Expression ProfilingGene Regulatory NetworksHeart Valve DiseasesHumansMacrophagesadipokinesCircadian clockscoronary artery diseaseepicardial adipose tissuemacrophages

Identifiers

PMID38813696
PMCPMC11208064

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.