Article in Development (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Nikaya PolsaniDepartment of Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0001-5343-4759
Theodora YungProgram in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0002-5435-0917
Evan ThomasProgram in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Melissa Phung-RojasDepartment of Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0003-4348-2727
Isha GuptaDepartment of Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Julie DenkerDepartment of Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Kimberly LauProgram in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Xiaotian FengDepartment of Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0001-8736-5536
Beatriz IbarraDepartment of Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0002-9744-2811
Sevan HopyanProgram in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0001-7201-8902
Radhika P AtitDepartment of Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0002-3492-6552
Funding
TRAINING PROGRAM IN MUSCULOSKELETAL RESEARCHT32AR007505 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI TRIOLO, RONALD J · 1986 to 2023
$6.3M
Genetic mechanisms of craniofacial dermal developmentR01DE018470 · NIDCR · CASE WESTERN RESERVE UNIVERSITY · PI ATIT, RADHIKA P · 2007 to 2018
$3.5M
Substrate-mediated collective cell migration in calvarial bone expansion and diseaseR56DE030206 · NIDCR · CASE WESTERN RESERVE UNIVERSITY · PI ATIT, RADHIKA P, HARRIS, MATTHEW P · 2021 to 2021
$571k
Mechanisms of apical expansion in calvarial bone morphogenesisR21DE029348 · NIDCR · CASE WESTERN RESERVE UNIVERSITY · PI ATIT, RADHIKA P, HOPYAN, SEVAN · 2020 to 2021
$401k
Phospho-ERK1/2 in beta-catenin-dependent cranial lineage restrictionF31DE028487 · NIDCR · CASE WESTERN RESERVE UNIVERSITY · PI IBARRA, BEATRIZ ADRIANNA · 2018 to 2020
$94k
Canada First Research Excellence FundCanada First Research Excellence Fund/Medicine by Design MbDGQ-2021-04CIHR 168992CIHR MOP 126115Medicine by Design MbDGQ-2021-04NIAMS NIH HHS T32 AR-007505NIAMS NIH HHS T32 AR007505NIDCR NIH HHS F31 DE028487NIDCR NIH HHS R01 DE018470NIDCR NIH HHS R01-DE18470NIDCR NIH HHS R21 DE029348NIDCR NIH HHS R56 DE030206NIH HHSNIH HHS DE18470
6 · The paper itself
Abstract
Apical expansion of calvarial osteoblast progenitors from the cranial mesenchyme (CM) above the eye is integral to calvarial growth and enclosure of the brain. The cellular behaviors and signals underlying the morphogenetic process of calvarial expansion are unknown. Time-lapse light-sheet imaging of mouse embryos revealed calvarial progenitors intercalate in 3D in the CM above the eye, and exhibit protrusive and crawling activity more apically. CM cells express non-canonical Wnt/planar cell polarity (PCP) core components and calvarial osteoblasts are bidirectionally polarized. We found non-canonical ligand Wnt5a-/- mutants have less dynamic cell rearrangements and protrusive activity. Loss of CM-restricted Wntless (CM-Wls), a gene required for secretion of all Wnt ligands, led to diminished apical expansion of Osx+ calvarial osteoblasts in the frontal bone primordia in a non-cell autonomous manner without perturbing proliferation or survival. Calvarial osteoblast polarization, progressive cell elongation and enrichment for actin along the baso-apical axis were dependent on CM-Wnts. Thus, CM-Wnts regulate cellular behaviors during calvarial morphogenesis for efficient apical expansion of calvarial osteoblasts. These findings also offer potential insights into the etiologies of calvarial dysplasias.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Mesenchymal Wnts are required for morphogenetic movements of calvarial osteoblasts during apical expansion. · full record | Socratic