Evidence map›Paper›PMID 38815331›Full record

ArticleRedox biology2024

Cystine/glutamate antiporter xCT controls skeletal muscle glutathione redox, bioenergetics and differentiation.

Michel N Kanaan, Chantal A Pileggi, Charbel Y Karam, Luke S Kennedy, Claire Fong-McMaster, Miroslava Cuperlovic-Culf, Mary-Ellen Harper

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michel N KanaanDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada; Ottawa Institute of Systems Biology, University of Ottawa, ON, K1H 8M5, Canada; Dr. Eric Poulin Centre for Neuromuscular Disease (CNMD), University of Ottawa, ON, K1H 8M5, Canada.
Chantal A PileggiDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada; Ottawa Institute of Systems Biology, University of Ottawa, ON, K1H 8M5, Canada.
Charbel Y KaramDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada; Ottawa Institute of Systems Biology, University of Ottawa, ON, K1H 8M5, Canada.
Luke S KennedyDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada; Ottawa Institute of Systems Biology, University of Ottawa, ON, K1H 8M5, Canada.
Claire Fong-McMasterDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada; Ottawa Institute of Systems Biology, University of Ottawa, ON, K1H 8M5, Canada.
Miroslava Cuperlovic-CulfDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada; Ottawa Institute of Systems Biology, University of Ottawa, ON, K1H 8M5, Canada; National Research Council of Canada, Digital Technologies Research Centre, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada.
Mary-Ellen HarperDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada; Ottawa Institute of Systems Biology, University of Ottawa, ON, K1H 8M5, Canada. Electronic address: mharper@uottawa.ca.

Funding

Canadian Institutes of Health Research (CIHR) FDN-143278
6 · The paper itself

Abstract

Cysteine, the rate-controlling amino acid in cellular glutathione synthesis is imported as cystine, by the cystine/glutamate antiporter, xCT, and subsequently reduced to cysteine. As glutathione redox is important in muscle regeneration in aging, we hypothesized that xCT exerts upstream control over skeletal muscle glutathione redox, metabolism and regeneration. Bioinformatic analyses of publicly available datasets revealed that expression levels of xCT and GSH-related genes are inversely correlated with myogenic differentiation genes. Muscle satellite cells (MuSCs) isolated from Slc7a11

Indexed as

Amino Acid Transport System y+Cell DifferentiationEnergy MetabolismGlutathioneMuscle, SkeletalOxidation-ReductionAnimalsCystineMiceMuscle DevelopmentMuscle Fibers, SkeletalSatellite Cells, Skeletal MuscleAmino Acid Transport System y+CystineGlutathioneSlc7a11 protein, mouseGlutathioneGlycolysisMitochondriaMyogenesisOxidative phosphorylationRedox

Identifiers

PMID38815331
PMCPMC11167394

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.