Evidence map›Paper›PMID 38815760›Full record

ArticleJournal of affective disorders2024

The effects of psychotherapy for anhedonia on subcortical brain volumes measured with ultra-high field MRI.

Kathryn Gibson, Paul Cernasov, Martin Styner, Erin C Walsh, Jessica L Kinard, Lisalynn Kelley, Joshua Bizzell, Rachel Phillips, Courtney Pfister, McRae Scott and 6 more

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02874534 nacompletednot on this map

Development of a Novel Transdiagnostic Intervention for Anhedonia - R61 Phase

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2017 to 2019Enrolled57ConditionsAnhedoniaArmsBehavioral Activation, Mindfulness Treatment
NCT04036136 nacompletednot on this map

Development of a Novel Transdiagnostic Intervention for Anhedonia - R33 Phase

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2019 to 2023Enrolled116ConditionsAnhedoniaArmsBehavioral Activation, Mindfulness Treatment
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kathryn GibsonDepartment of Psychiatry, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA. Electronic address: kathryn_gibson@med.unc.edu.
Paul CernasovDepartment of Psychology and Neuroscience, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA.
Martin StynerDepartment of Psychiatry, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA.
Erin C WalshDepartment of Psychiatry, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA.
Jessica L KinardCarolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27510, USA.
Lisalynn KelleyDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA.
Joshua BizzellDepartment of Psychiatry, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA; Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27510, USA.
Rachel PhillipsDepartment of Psychology and Neuroscience, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA.
Courtney PfisterDepartment of Psychology and Neuroscience, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA.
McRae ScottDepartment of Psychology and Neuroscience, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA.
Louise FreemanDepartment of Psychology and Neuroscience, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA.
Angela PisoniDepartment of Psychology and Neuroscience, Duke University, Durham, NC 27505, USA.
Gabriela A NagyDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA.
Jason A OliverDepartment of Family and Preventative Medicine, University of Oklahoma, Oklahoma City, OK 73117, USA.
Moria J SmoskiDepartment of Psychology and Neuroscience, Duke University, Durham, NC 27505, USA.
Gabriel S DichterDepartment of Psychiatry, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA; Department of Psychology and Neuroscience, University of North Carolina-Chapel Hill, Chapel Hill, NC 27514, USA; Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27510, USA.

Funding

North Carolina Translational and Clinical Sciences Institute (NC TraCS)UM1TR004406 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICHOLAS J SHAHEEN · 2023 to 2026
$37.5M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark D Shen · 2020 to 2026
$9.7M
Development of A Novel Transdiagnostic Intervention for AnhedoniaR33MH110027 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DICHTER, GABRIEL S, SMOSKI, MORIA J. · 2019 to 2021
$2.3M
Development of A Novel Transdiagnostic Intervention for AnhedoniaR61MH110027 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DICHTER, GABRIEL S, SMOSKI, MORIA J. · 2017 to 2018
$1.9M
Neuroinflammatory Mechanisms of Anhedonia in Major DepressionK23MH113733 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WALSH, ERIN · 2018 to 2023
$866k
NCATS NIH HHS UM1 TR004406NICHD NIH HHS P50 HD103573NIMH NIH HHS K23 MH113733NIMH NIH HHS R33 MH110027NIMH NIH HHS R61 MH110027
6 · The paper itself

Abstract

backgroundAnhedonia is a transdiagnostic symptom often resistant to treatment. The identification of biomarkers sensitive to anhedonia treatment will aid in the evaluation of novel anhedonia interventions.

methodsThis is an exploratory analysis of changes in subcortical brain volumes accompanying psychotherapy in a transdiagnostic anhedonic sample using ultra-high field (7-Tesla) MRI. Outpatients with clinically impairing anhedonia (n = 116) received Behavioral Activation Treatment for Anhedonia, a novel psychotherapy, or Mindfulness-Based Cognitive Therapy (ClinicalTrials.gov Identifiers NCT02874534 and NCT04036136). Subcortical brain volumes were estimated via the MultisegPipeline, and regions of interest were the amygdala, caudate nucleus, hippocampus, pallidum, putamen, and thalamus. Bivariate mixed effects models estimated pre-treatment relations between anhedonia severity and subcortical brain volumes, change over time in subcortical brain volumes, and associations between changes in subcortical brain volumes and changes in anhedonia symptoms.

resultsAs reported previously (Cernasov et al., 2023), both forms of psychotherapy resulted in equivalent and significant reductions in anhedonia symptoms. Pre-treatment anhedonia severity and subcortical brain volumes were not related. No changes in subcortical brain volumes were observed over the course of treatment. Additionally, no relations were observed between changes in subcortical brain volumes and changes in anhedonia severity over the course of treatment. LIMITATIONS: This trial included a modest sample size and did not have a waitlist-control condition or a non-anhedonic comparison group.

conclusionsIn this exploratory analysis, psychotherapy for anhedonia was not accompanied by changes in subcortical brain volumes, suggesting that subcortical brain volumes may not be a candidate biomarker sensitive to response to psychotherapy.

Indexed as

AnhedoniaBrainMagnetic Resonance ImagingAdultCognitive Behavioral TherapyFemaleHumansMaleMiddle AgedMindfulnessOrgan SizePsychotherapyTreatment OutcomeYoung AdultAnhedoniaCaudate nucleusClinical trialPsychotherapyStructural MRI

Identifiers

PMID38815760
PMCPMC11259027

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.