ArticleNature immunology2024
Antitumor progenitor exhausted CD8
Abstract read
In one paragraph
Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Dynamic immune profiling predicts response to radiation plus anti-PD-1 therapy in oligometastatic renal cell carcinoma.Nature communications · 2026Trial
- Intratumoral PD-1Medical oncology (Northwood, London, England) · 2026Article
- Progenitor T cells drive chronic pulmonary type 2 inflammation.Nature immunology · 2026Article
- Tumor-distal mediastinal lymph nodes harbor tumor-related progenitor exhausted T cells in lung cancer after neoadjuvant chemoimmunotherapy.Cell reports. Medicine · 2026Article
- Decoding T cell exhaustion in the tumour microenvironment.Experimental & molecular medicine · 2026Review
- PARP inhibition combined with a T-cell receptor β chain-directed antibody fusion molecule drives polyclonal antitumor immunity and tumor regression.Journal for immunotherapy of cancer · 2026Article
- A post-translational regulatory map of chronic antigen-driven human T cell dysfunction.bioRxiv : the preprint server for biology · 2026Article
- The ubiquitin ligase KLHL6 drives resistance to CD8Nature · 2026Article
- Regulators of CD8Nature reviews. Immunology · 2026Review
- Single-Cell Clonal Lineage Tracing Identifies the Transcriptional Program Controlling the Cell-Fate Decisions by Neoantigen-Specific CD8+ T Cells.Cancer immunology research · 2026Article
- Article
- Regulation of T cell exhaustion and stemness: molecular mechanisms and implications for cancer immunotherapy.Cellular & molecular immunology · 2026Review
- Cytotoxic T-cell exhaustion analyses by in situ single-cell immunofluorescence in relation to colorectal cancer patient age, tissue bacteria and mortality.BMJ oncology · 2026Article
- Stem-like T cells in cancer immunotherapy: biology, regulation and therapeutic targeting.Frontiers in immunology · 2026Review
- The evolving role of the immune microenvironment of tumor draining lymph nodes in the development of biomarkers of non-small cell lung cancer.Frontiers in oncology · 2026Review
- Immune evasion driven by lipid metabolic reprogramming in endocrine-resistant HRFrontiers in immunology · 2026Review
- Antigen-presenting cells as arbiters of mucosal tolerance and immunity.Nature immunology · 2025Review
- Review
- A Dapl1Science advances · 2025Article
- Controlling T cell-tumor cell interaction with a biomimetic physical barrier for cancer immunotherapy.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Xin LanDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Tian MiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Shanta AlliDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Cliff GuyDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Mohamed Nadhir DjekidelCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Xueyan LiuDepartment of Mathematics, University of New Orleans, New Orleans, LA, USA.
Shannon BoiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Partha ChowdhuryDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Minghong HeDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Dietmar ZehnDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.ORCID http://orcid.org/0000-0003-1393-8527
Yongqiang FengDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-2320-5063
Ben YoungbloodDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA. benjamin.youngblood@stjude.org.ORCID http://orcid.org/0000-0002-1261-9957
Funding
EPIGENETIC REPROGRAMMING OF T CELL EXHAUSTION TO ENHANCE TUMOR IMMUNOTHERAPYR01CA237311 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Benjamin Alan Youngblood · 2020 to 2026
$2.9MRobust immune tolerance conferred by Foxp3 transcriptional regulationR01AI153138 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI FENG, YONGQIANG · 2021 to 2025
$2.2MEpigenetic Regulation of T-cell Exhaustion During Treated Chronic HIV InfectionR01AI114442 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI YOUNGBLOOD, BENJAMIN ALAN · 2015 to 2019
$2.1MDetermination of chromatin protein dynamics in CD8 T cellsR21AI173909 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI FENG, YONGQIANG · 2023 to 2024
$501kNIAID NIH HHS R21 AI173909U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI114442U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics) R01CA237311
Abstract
The durability of an antitumor immune response is mediated in part by the persistence of progenitor exhausted CD8
Indexed as
Carcinoma, Lewis LungCD8-Positive T-LymphocytesHepatocyte Nuclear Factor 1-alphaMice, Inbred C57BLReceptors, Antigen, T-CellAnimalsCell DifferentiationCell Self RenewalDendritic CellsEarly Growth Response Protein 2Lymphocyte ActivationMiceMice, KnockoutMice, TransgenicSignal TransductionEarly Growth Response Protein 2Egr2 protein, mouseHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseReceptors, Antigen, T-Cell
Identifiers
PMID
38816618What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.