Evidence map›Paper›PMID 38817436›Full record

ArticleNanoscale advances2024

Graphene oxide and oxidized carbon nanodiscs as biomedical scaffolds for the targeted delivery of quercetin to cancer cells.

Panagiota Zygouri, Grigorios Tsiodoulos, Marina Angelidou, Eirini Papanikolaou, Antrea-Maria Athinodorou, Yannis V Simos, Konstantinos Spyrou, Mohammed Subrati, Antonios Kouloumpis, Angela S Kaloudi and 6 more

Abstract read
In one paragraph

Article in Nanoscale advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Navigating theNanoscale advances · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Potential of Carbon Nanodots (CNDs) in Cancer Treatment.Nanomaterials (Basel, Switzerland) · 2025
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Panagiota ZygouriDepartment of Materials Science and Engineering, University of Ioannina 45110 Ioannina Greece konstantinos.spyrou1@gmail.com.ORCID https://orcid.org/0000-0002-7137-6633
Grigorios TsiodoulosDepartment of Maxillofacial, Faculty of Medicine, School of Health Sciences, University of Ioannina 45110 Ioannina Greece.
Marina AngelidouDepartment of Physiology, Faculty of Medicine, School of Health Sciences, University of Ioannina Ioannina 45110 Greece.
Eirini PapanikolaouNanomedicine and Nanobiotechnology Research Group, University of Ioannina Ioannina 45110 Greece isimos@uoi.gr.
Antrea-Maria AthinodorouDepartment of Physiology, Faculty of Medicine, School of Health Sciences, University of Ioannina Ioannina 45110 Greece.
Yannis V SimosNanomedicine and Nanobiotechnology Research Group, University of Ioannina Ioannina 45110 Greece isimos@uoi.gr.ORCID https://orcid.org/0000-0003-1764-8906
Konstantinos SpyrouDepartment of Materials Science and Engineering, University of Ioannina 45110 Ioannina Greece konstantinos.spyrou1@gmail.com.ORCID https://orcid.org/0000-0002-2032-8439
Mohammed SubratiDepartment of Materials Science and Engineering, University of Ioannina 45110 Ioannina Greece konstantinos.spyrou1@gmail.com.
Antonios KouloumpisDepartment of Materials Science and Engineering, University of Ioannina 45110 Ioannina Greece konstantinos.spyrou1@gmail.com.ORCID https://orcid.org/0000-0002-8738-3141
Angela S KaloudiDepartment of Materials Science and Engineering, University of Ioannina 45110 Ioannina Greece konstantinos.spyrou1@gmail.com.ORCID https://orcid.org/0009-0006-4052-0002
Georgios AsimakopoulosDepartment of Materials Science and Engineering, University of Ioannina 45110 Ioannina Greece konstantinos.spyrou1@gmail.com.
Konstantinos TsamisNanomedicine and Nanobiotechnology Research Group, University of Ioannina Ioannina 45110 Greece isimos@uoi.gr.
Dimitrios PeschosNanomedicine and Nanobiotechnology Research Group, University of Ioannina Ioannina 45110 Greece isimos@uoi.gr.
Patra VezyrakiNanomedicine and Nanobiotechnology Research Group, University of Ioannina Ioannina 45110 Greece isimos@uoi.gr.
Vasileios RagosDepartment of Maxillofacial, Faculty of Medicine, School of Health Sciences, University of Ioannina 45110 Ioannina Greece.
Dimitrios P GournisDepartment of Materials Science and Engineering, University of Ioannina 45110 Ioannina Greece konstantinos.spyrou1@gmail.com.ORCID https://orcid.org/0000-0003-4256-8190

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeting cancer cells without affecting normal cells poses a particular challenge. Nevertheless, the utilization of innovative nanomaterials in targeted cancer therapy has witnessed significant growth in recent years. In this study, we examined two layered carbon nanomaterials, graphene and carbon nanodiscs (CNDs), both of which possess extraordinary physicochemical and structural properties alongside their nano-scale dimensions, and explored their potential as nanocarriers for quercetin, a bioactive flavonoid known for its potent anticancer properties. Within both graphitic allotropes, oxidation results in heightened hydrophilicity and the incorporation of oxygen functionalities. These factors are of great significance for drug delivery purposes. The successful oxidation and interaction of quercetin with both graphene (GO) and CNDs (oxCNDs) have been confirmed through a range of characterization techniques, including FTIR, Raman, and XPS spectroscopy, as well as XRD and AFM.

Identifiers

PMID38817436
PMCPMC11134231

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.