Evidence map›Paper›PMID 38817802›Full record

ArticleDrugs in context2024

Long-term pasireotide-LAR treatment in the personalized therapy of patients with complex acromegaly: a collection of clinical experiences.

Sabrina Chiloiro, Marialuisa Appetecchia, Antonio Bianchi, Denise Costa, Christine De Acetis, Patrizia Gargiulo, Antonella Giampietro, Andrea M Isidori, Marie-Lise Jaffrain-Rea, Marina Passeri and 3 more

Abstract read
In one paragraph

Article in Drugs in context, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sabrina ChiloiroDipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.
Marialuisa AppetecchiaOncological Endocrinology Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Antonio BianchiDipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.
Denise CostaDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Christine De AcetisUnità Operativa Complessa di Endocrinologia e Diabetologia a Valenza Aziendale - ASL Teramo, Teramo, Italy.
Patrizia GargiuloDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Antonella GiampietroDipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.
Andrea M IsidoriDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Marie-Lise Jaffrain-ReaDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Marina PasseriOspedale CTO-Alesini Roma Divisione di Endocrinologia, Rome, Italy.
Francesca PigliaruUnita di Endocrinologia, Policlinico Casula, AOU Cagliari, Cagliari, Italy.
Maurizio PoggiUOC Endocrinologia, Azienda Ospedaliera Sant'Andrea, Rome, Italy.
Laura De MarinisDipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pasireotide-LAR is recommended as a second-line treatment for patients with acromegaly. Although the effects of pasireotide-LAR have been well characterized in clinical studies, real-practice evidence is scant, especially in the long term and within the individualization of therapy in patients with comorbidities. To provide additional insight on the individualized approach to acromegaly management, six clinical cases of complex acromegaly treated with pasireotide-LAR for more than 5 years were reported. Pasireotide-LAR allowed the normalization of insulin-like growth factor 1 (IGF1) values in all patients and reduced tumour residue volume where present. A good safety profile and long-term tolerability were also reported.

Indexed as

acromegalydiabetes mellitusgrowth hormoneIGF1pasireotide-LARsomatotropinoma

Identifiers

PMID38817802
PMCPMC11139163

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.