Evidence map›Paper›PMID 38817847›Full record

ArticleJCEM case reports2024

Tumor-Induced Osteomalacia due to Sarcomatoid Non-Small Cell Lung Carcinoma Confounded by Drug-Induced Fanconi Syndrome.

Bassam AlHamer, Ajit Singh, Carmen Patrascu, Mona Al Mukaddam

Abstract readCase Reports
In one paragraph

Article in JCEM case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Tumor-Induced Osteomalacia in a Patient WithJTO clinical and research reports · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bassam AlHamerUniversity of Pennsylvania Health System, Pennsylvania Hospital Department of Internal Medicine, Philadelphia, PA 19107, USA.ORCID https://orcid.org/0000-0002-4250-1052
Ajit SinghUniversity of Pennsylvania Health System, Pennsylvania Hospital Department of Internal Medicine, Philadelphia, PA 19107, USA.ORCID https://orcid.org/0000-0002-0567-5870
Carmen PatrascuUniversity of Pennsylvania Health System, Pennsylvania Hospital Nephrology, Philadelphia, PA 19107, USA.ORCID https://orcid.org/0009-0003-8505-3880
Mona Al MukaddamUniversity of Pennsylvania Health System, Division of Endocrinology, Diabetes and Metabolism, Philadelphia, PA 19104, USA.ORCID https://orcid.org/0000-0002-7138-596X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor-induced osteomalacia (TIO) is an exceedingly rare paraneoplastic condition characterized by hypophosphatemia, osteomalacia, fragility fractures, and fatigue. A 39-year-old man was assessed for hemoptysis, pathological rib fractures, and fatigue, and was found to have a chest mass with lung metastasis. Biopsy of the mass suggested high-grade epithelioid and spindle cell neoplasm. He was initially treated for soft tissue sarcoma with an ifosfamide-based regimen and developed Fanconi syndrome that resolved on cessation of ifosfamide. Serum phosphate remained low. A low tubular maximum reabsorption of phosphate to glomerular filtration rate ratio (TmP/GFR) indicated disproportionate phosphaturia, while a severely elevated fibroblast growth factor-23 (FGF23) level enabled a diagnosis of TIO. He was started on phosphate and calcitriol supplementation. Subsequent next-generation sequencing demonstrated a

Indexed as

burosumabFanconifibroblast growth factor-23hypophosphatemiaselpercatinibtumor-induced osteomalacia

Identifiers

PMID38817847
PMCPMC11137757

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.