ArticleJournal of the American Heart Association2024
Diabetes-Related Macrovascular Complications Are Associated With an Increased Risk of Diabetic Microvascular Complications: A Prospective Study of 1518 Patients With Type 1 Diabetes and 20 802 Patients With Type 2 Diabetes in the UK Biobank.
Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect of educational program for patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2026Pooled it
- Sodium glucose co-transporter 2 (SGLT2) inhibitors versus dipeptidyl peptidase-4 (DPP-4) inhibitors and the risk of Atrial Fibrillation in patients with type 2 diabetes mellitus: a meta-analysis.BMC cardiovascular disorders · 2025Pooled it
- Cardiovascular risk equations in type 1 diabetes: from generic models to personalized prediction.Annals of medicine · 2026Review
- Glycemic control and renal function decline in patients with chronic coronary syndrome: A multicenter cohort study.Journal of diabetes investigation · 2026Observational
- Diabetes Duration Is Associated with Declining Kidney Function: eGFR and CKD Burden Across Duration.Journal of clinical medicine · 2026Article
- Triglyceride-glucose index, genetic susceptibility, and trajectory of microvascular multimorbidity in type 2 diabetes.Scientific reports · 2026Article
- Clinical effects of Yiqi-Yangyin-Huoxue granules in the management of type 2 diabetes mellitus and early vascular aging: a randomized, double-blind, placebo-controlled trial protocol.Frontiers in medicine · 2026Article
- National divergence in cardio-kidney-metabolic syndrome burden and implications for health policy: a global burden of disease analysis with projections to 2050.Frontiers in public health · 2026Article
- Construction of a dynamic prediction model for diabetic retinopathy risk in adults with adult-onset type 1 diabetes: a real-world longitudinal cohort study.Frontiers in clinical diabetes and healthcare · 2026Article
- Self-care behaviors and correlates among adults with type 2 diabetes in Northwest China.Frontiers in endocrinology · 2026Article
- Oral and cardiometabolic health through the lens of biobanks and large-scale epidemiologic research.Frontiers in oral health · 2026Review
- The prevalence of anemia among type 2 diabetes mellitus with respect to renal function at a tertiary care hospital: A case-control study.Bioinformation · 2026Article
- Low Ankle-Brachial Index Is Associated With Albuminuria and Diabetic Kidney Disease in Type 2 Diabetes; A Cross Sectional Study.Endocrinology, diabetes & metabolism · 2025Article
- Longitudinal patterns of obesity index changes and risk of incident rheumatoid arthritis: evidence from a population-based cohort.Arthritis research & therapy · 2025Article
- Beyond blood pressure and glucose: exploring potential biochemical predictors of cardiovascular disease risk in patients with type 2 diabetes mellitus and co-morbid hypertension.BMC endocrine disorders · 2025Article
- Unveiling biomarkers via plasma metabolome profiling for diabetic macrovascular and microvascular complications.Cardiovascular diabetology · 2025Article
- The G-allele of rs10830963 inInternational journal of molecular sciences · 2025Article
- A Metabolic Signature Specific to the Patients with Type 2 Diabetes and its Association with the Pathogenesis of Diabetic-Foot Syndrome.Journal of cardiovascular translational research · 2025Article
- Protective effects of S-adenosyl methionine on oxidative stress and tissue damage in STZ-induced diabetic rats.Amino acids · 2025Article
- Sea buckthorn flavonoids and their derivatives: potential natural compounds for the treatment of diabetic cardiomyopathy.Frontiers in pharmacology · 2025Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetic vascular complications share common pathophysiological mechanisms, but the relationship between diabetes-related macrovascular complications (MacroVCs) and incident diabetic microvascular complications remains unclear. We aimed to investigate the impact of MacroVCs on the risk of microvascular complications. METHODS AND
resultsThere were 1518 participants with type 1 diabetes (T1D) and 20 802 participants with type 2 diabetes from the UK Biobank included in this longitudinal cohort study. MacroVCs were defined by the presence of macrovascular diseases diagnosed after diabetes at recruitment, including coronary heart disease, peripheral artery disease, stroke, and ≥2 MacroVCs. The primary outcome was incident microvascular complications, a composite of diabetic retinopathy, diabetic kidney disease, and diabetic neuropathy. During a median (interquartile range) follow-up of 11.61 (5.84-13.12) years and 12.2 (9.50-13.18) years, 596 (39.3%) and 4113 (19.8%) participants developed a primary outcome in T1D and type 2 diabetes, respectively. After full adjustment for conventional risk factors, Cox regression models showed significant associations between individual as well as cumulative MacroVCs and the primary outcome, except for coronary heart disease in T1D (T1D: diabetes coronary heart disease: 1.25 [0.98-1.60]; diabetes peripheral artery disease: 3.00 [1.86-4.84]; diabetes stroke: 1.71 [1.08-2.72]; ≥2: 2.57 [1.66-3.99]; type 2 diabetes: diabetes coronary heart disease: 1.59 [1.38-1.82]; diabetes peripheral artery disease: 1.60 [1.01-2.54]; diabetes stroke: 1.50 [1.13-1.99]; ≥2: 2.66 [1.92-3.68]). Subgroup analysis showed that strict glycemic (glycated hemoglobin <6.5%) and blood pressure (<140/90 mm Hg) control attenuated the association.
conclusionsIndividual and cumulative MacroVCs confer significant risk of incident microvascular complications in patients with T1D and type 2 diabetes. Our results may facilitate cost-effective high-risk population identification and development of precise prevention strategies.
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